Now showing items 1-10 of 13
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
Glycine Protection of PC-12 Cells Against Injury by ATP-Depletion
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-06)
A distinctive mechanism of cell injury during ATP depletion involves the loss of cellular glycine. The current study examined whether provision of glycine during ATP depletion can prevent injury in PC-12 cells, a cell line ...
Regulation of Myo-Inositol Homeostasis in Differentiated Human NT2-N Neurons
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-05)
We have investigated the possible role of second messengers on inositol homeostasis in NT2-N cells, human central nervous system neurons obtained by terminal differentiation of teratocarcinoma precursors. Uptake of inositol ...
Statistical Analysis of Multiplex Brain Gene Expression Images
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-10)
Analysis of variance (ANOVA) was employed to investigate 9,000 gene expression patterns from brains of both normal mice and mice with a pharmacological model of Parkinson's disease (PD). The data set was obtained using ...
William Hogarth, Unwitting Neurochemist?
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-10)
William Hogarth's famous etching Gin Lane is often used to illustrate the debilitating results of alcohol addiction. Less well known is the companion etching Beer Street in which death, murder and squalor are replaced by ...
Studies of Posttranslational Modifications in Spiny Dogfish Myelin Basic Protein
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2001-05)
The objective of this investigation was to determine whether nonmammalian myelin basic protein contained charge isomers resulting from extensive posttranslational modifications as seen in mammalian MBP. Four charge isomer ...
Linear and Nonlinear Measures and Seizure Anticipation in Temporal Lobe Epilepsy
(Kluwer Academic Publishers; Springer Science+Business Media, 2003-11)
In a recent paper, we showed that the value of a nonlinear quantity computed from scalp electrode data was correlated with the time to a seizure in patients with temporal lobe epilepsy. In this paper we study the relationship ...
Negative regulation and immune effects of apoptotic cell clearance in the lung: SIRPa and miR34a.
(2014)
Apoptotic cell clearance (efferocytosis) is the essential biological process by which dead cells, called apoptotic cells (AC), are engulfed and recycled by living cells called phagocytes. This process is regulated by many ...
Characterization of the function of the LMAN1 ER cargo receptor in vivo.
(2016)
Combined deficiency of coagulation factors V and VIII (F5F8D) is an autosomal recessive bleeding disorder caused by defects in LMAN1 or MCFD2, which form the only known mammalian secretory ER cargo-receptor. LMAN1/MCFD2 ...
Design and Testing Novel Wearable Instrumentation for Assessing Pelvic Floor Function and Exploring Continence Mechanisms
(2020)
Urinary incontinence (UI) and fecal incontinence (FI) affect 20% of North Americans, with a higher prevalence in women and the elderly. The prevention and treatment of these conditions unfortunately leaves much to be ...