Now showing items 31-40 of 257
Excitatory amino acidergic pathways and receptors in the basal ganglia
(Springer-Verlag, 1991-10)
The striatum receives the majority of excitatory amino acidergic input to the basal ganglia from neocortical and allocortical sources. The subthalamic nucleus and the substantia nigra also receive excitatory amino acidergic ...
A novel phosphate-regulated expression vector in Escherichia coli
(Elsevier, 1990-05-31)
The ugp promoter (pugp) responsible for expression of the binding-protein-dependent sn-glycerol-3-phosphate transport system in Escherichia coli was cloned into a small multicopy plasmid pTER5, a derivative of pBR322, ...
mnd2: A New Mouse Model of Inherited Motor Neuron Disease
(Elsevier, 1993-06)
The autosomal recessive mutation mnd2 results in early onset motor neuron disease with rapidly progressive paralysis, severe muscle wasting, regression of thymus and spleen, and death before 40 days of age. mnd2 has been ...
TECHNICAL REPORT: Rapid confirmation of gene targeting in embryonic stem cells using two long-range PCR techniques
(Kluwer Academic Publishers; Chapman and Hall ; Springer Science+Business Media, 1998-03)
Gene targeting in mouse embryonic stem (ES) cells generally includes the analysis of numerous colonies to identify a few with mutations resulting from homologous recombination with a targeting vector. Thus, simple and ...
Localization of the gene encoding R[kappa]B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25
(Elsevier, 1992-10)
Although NF (nuclear factor)-[kappa]B binds in vitro to several of the [kappa]B regulatory elements found in cellular and viral genes, another DNA binding protein, R[kappa]B, also binds to a related variant of the [kappa]B ...
Gene expression of the insulin-like growth factors and their receptors in human neuroblastoma cell lines
(Elsevier, 1992-10)
Insulin-like growth factors (IGF) I and II are polypeptides with both growth-promoting and insulin-like metabolic effects. The developmentally specific expression of IGF I and II in the nervous system implies a role for ...
Chemical permeabilization and in situ removal of daidzein from biologically viable soybean (Glycine max) seeds
(Kluwer Academic Publishers; Chapman and Hall ; Springer Science+Business Media, 1998-09)
After 24 h of chemical permeabilization with 20% (v/v) methanol at 25 °C, the amount of daidzein released from soybean seeds is 15 to 20% of the amount (0.0423 ± 0.0045 mg/g seed dry wt) obtained by physical grinding. With ...
Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A
(Elsevier, 1990-10)
The syndrome of multiple endocrine neoplasia type 2B (MEN 2B) resembles that of MEN 2A in that both include medullary carcinoma of the thyroid, pheochromocytoma, and autosomal dominant inheritance, but is distinct in that ...
Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backross
(Elsevier, 1991-07)
Ames dwarf (df) is an autosomal recessive mutation characterized by severe dwarfism and infertility. This mutation provides a mouse model for panhypopituitarism. The dwarf phenotype results from failure in the differentiation ...
Tissue-specific expression of the human neuropeptide Y gene in transgenic mice
(Elsevier, 1992-06)
Neuropeptide Y (NPY) is the most abundant neuropeptide detected in the mammalian brain, and is found throughout the central and peripheral nervous systems. This peptide is a proposed regulator of appetite, blood pressure, ...