Now showing items 51-60 of 257
The effect of phenotype variation on detection of linkage in the COGA data
(Wiley Subscription Services, Inc., A Wiley Company, 1999)
Error in phenotypic measurement can significantly compromise ability to detect linkage. We assessed the impact of introducing phenotypic measurement error on our ability to detect a quantitative trait locus in the Collaborative ...
Molecular Characterization of the Murine Neural Retina Leucine Zipper Gene, Nrl
(Elsevier, 1993-11)
The NRL gene (D14S46E) is expressed in cells of human retina and encodes a putative DNA-binding protein of the leucine zipper family. Here we describe the analysis of the murine homolog of the NRL gene, Nrl. Various cDNAs ...
Continuous medium perfusion leads to long-term cell viability and oxygen production in high-density photobioreactors
(Kluwer Academic Publishers; Chapman & Hall, London ; Springer Science+Business Media, 1995-11)
A light-emitting diode-based photobioreactor (LED-based PBR) operated in a continuous perfusion mode with a perfusion rate of 3 to 6 reactor volumes a day supports high-density algal cultures, of cell concentrations up to ...
Impact of a Simple Inexpensive Quality Assurance Effort on Physician's Choice of Thrombolytic Agents and Door-to-Needle Time: Implication for Costs of Management
(Kluwer Academic Publishers; Springer Science+Business Media, 1998-01)
The objective of this study were to assess the impact of a quality assurance effort on the door-to-needle time and the choice of thrombolytic agent for the management of acute myocardial infarction in the emergency department. ...
Individual differences in sensitivity to nicotine: Implications for genetic research on nicotine dependence
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1995-03)
Recent evidence suggests that cigarette smoking has a heritability index around 53%. While related research on underlying mechanisms also supports the idea that genetic factors contribute to nicotine dependence—as well as ...
A rapid attenuation of muscarinic agonist stimulated phosphoinositide hydrolysis precedes receptor sequestration in human SH-SY-5Y neuroblastoma cells
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-05)
Agonist occupancy of muscarinic cholinergic receptors in human SH-SY-5Y neuroblastoma cells elicited two kinetically distinct phases of phosphoinositide hydrolysis when monitored by either an increased mass of inositol ...
Repeated haloperidol increases both calmodulin and a calmodulin-binding protein in rat striatum
(Elsevier, 1994-12)
Repeated treatment with the antipsychotic drug, haloperidol, leads to an increased behavioral sensitivity to dopamine agonists exhibited upon withdrawal from the drug. An increase in the particulate content of the endogenous ...
Characterization of the Determinant (traB) Encoding Sex Pheromone Shutdown by the Hemolysin/Bacteriocin Plasmid pAD1 in Enterococcus faecalis
(Elsevier, 1994-03)
pAD1 is a hemolysin/bacteriocin plasmid originally identified in Enterococcus faecalis DS16. It encodes a mating response to a peptide sex pheromone, cAD1, secreted by recipient bacteria. Once pAD1 is acquired, production ...
Alu-PCR: Characterization of a chromosome 6-specific hybrid mapping panel and cloning of chromosome-specific markers
(Elsevier, 1992-03)
The Alu-polymerase chain reaction (Alu-PCR) was applied to selectively amplify DNA sequences from human chromosome 6 using a single primer (A1) directed to the human Alu consensus sequence. A specific amplification pattern ...
Isolation, characterization, and chromosomal mapping of mouse P450 17[alpha]-hydroxylase/C17-20 lyase
(Elsevier, 1991-05)
Cytochrome P450 17[alpha]-hydroxylase/C17-20 lyase (P45017[alpha]) catalyzes the conversion of C-21 steroids to C-19 steroids in gonads. A full-length mouse cDNA encoding P45017[alpha] was isolated from a mouse Leydig cell ...