Now showing items 761-768 of 768
Role of Histone Methyltransferase SET-4 in Developmental Plasticity and Longevity
(2017)
FoxO transcription factors promote longevity across diverse organisms through upregulation of
parallel stress responses. Therefore, understanding how FoxO activity is regulated may provide
insights for improving overall ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...
Regulation of Bone Formation and Pathology by Local Actions of Leptin in the Bone Marrow.
(2011)
Site-specific adipose content of the bone marrow has been noted since the inclusion
of meat into the hominid diet, evidenced by marrow removal from ungulate limb
bones, 2.6 million years ago. Association between marrow fat ...
Role of CHD7 in Neural Development and Maintenance.
(2011)
Normal tissue development and maintenance require precise timing and correct localization of gene expression. Several lines of evidence indicate that the chromodomain (CHD) family of proteins are critical regulators of ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...
Mimicking partial to total placental insufficiency in a rabbit model of cerebral palsy
(Springer International PublishingWiley Periodicals, Inc., 2022-12)
All placental abruptions begin as partial abruptions, which sometimes manifest as fetal bradycardia. The progression from partial to total abruption was mimicked by a new rabbit model of placental insufficiency, and we ...