Now showing items 21-30 of 203
Delayed neurotrophin treatment following deafness rescues spiral ganglion cells from death and promotes regrowth of auditory nerve peripheral processes: Effects of brain-derived neurotrophic factor and fibroblast growth factor
(Wiley Subscription Services, Inc., A Wiley Company, 2007-07)
The extent to which neurotrophic factors are able to not only rescue the auditory nerve from deafferentation-induced degeneration but also promote process regrowth is of basic and clinical interest, as regrowth may enhance ...
Super-stereotypy I: Enhancement of a complex movement sequence by systemic dopamine D1 agonists
(John Wiley & Sons, Inc., 2000-09-01)
Peripheral administration of D1 dopamine agonists elicits grooming behavior from rodents. The present study examined grooming behavior and the relative probability and stereotypy of a natural sequence of grooming movements ...
Heat shock factor 1-deficient mice exhibit decreased recovery of hearing following noise overstimulation
(Wiley Subscription Services, Inc., A Wiley Company, 2005-08-15)
Heat shock proteins (Hsps) can enhance cell survival in response to stress. Heat shock factor 1 (Hsf1) is the major transcription factor that regulates stress-inducible Hsp expression. We previously demonstrated the ...
Structure specific analysis of the hippocampus in temporal lobe epilepsy
(Wiley Subscription Services, Inc., A Wiley Company, 2009-06)
The hippocampus is a major structure of interest affected by temporal lobe epilepsy (TLE). Region of interest (ROI)-based analysis has traditionally been used to study hippocampal involvement in TLE, although spatial ...
Glycine Protection of PC-12 Cells Against Injury by ATP-Depletion
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-06)
A distinctive mechanism of cell injury during ATP depletion involves the loss of cellular glycine. The current study examined whether provision of glycine during ATP depletion can prevent injury in PC-12 cells, a cell line ...
Early NFΚB activation is inhibited during focal cerebral ischemia in interleukin-1Β-converting enzyme deficient mice
(Wiley Subscription Services, Inc., A Wiley Company, 2003-09-01)
Our previous study demonstrated that the inhibition of interleukin-1Β (IL-1Β) reduces ischemic brain injury; however, the molecular mechanism of the action of IL-1 in cerebral ischemia is unclear. We are investigating ...
Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest Α9-like receptors
(John Wiley & Sons, Inc., 2001-02-01)
The medial efferent system innervates outer hair cells in the organ of Corti. Neurotransmission at this synapse is mediated by acetylcholine (ACh) acting on nicotinic ACh receptors containing the Α9 subunit. In addition ...
Proportional myoelectric control of a virtual object to investigate human efferent control
(Springer-Verlag, 2004-12)
We used proportional myoelectric control of a one-dimensional virtual object to investigate differences in efferent control between the proximal and distal muscles of the upper limbs. Eleven subjects placed one of their ...
Convulsant activity of a non-peptidic δ-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats
(Springer-Verlag, 2002-10)
Abstract
Overview of Gene Targeting by Homologous Recombination
(Wiley Periodicals, Inc., 2002-10)
Overview of Gene Targeting by Homologous Recombination (Richard Mortensen, University of Michigan Medical School, Ann Arbor, Michigan).This overview describes the basic methodology and applications of homologous recombination. ...