Now showing items 31-40 of 203
Tracking Quantum Dot–Tagged Calcium Channels at Vertebrate Photoreceptor Synapses: Retinal Slices and Dissociated Cells
(Wiley Periodicals, Inc., 2013-01)
At synapses in the central nervous system, precisely localized assemblies of presynaptic proteins, neurotransmitter‐filled vesicles, and postsynaptic receptors are required to communicate messages between neurons. Our ...
Analyzing Binding Data
(Academic PressWiley Periodicals, Inc., 2010-07)
Measuring the rate and extent of radioligand binding provides information on the number of binding sites, and their affinity and accessibility of these binding sites for various drugs. This unit explains how to design and ...
Hippocampal involvement in contextual modulation of fear extinction
(Wiley Subscription Services, Inc., A Wiley Company, 2007-09)
Extinction of fear conditioning in animals is an excellent model for the study of fear inhibition in humans. Substantial evidence has shown that extinction is a new learning process that is highly context-dependent. Several ...
Modulation of morphine sensitization in the rat by contextual stimuli
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-08)
Rationale: The repeated administration of addictive drugs, such as amphetamine, cocaine, and morphine, produces a progressive enhancement (sensitization) of their psychomotor activating effects. We have previously shown ...
Remodeling of cholinergic input to the hippocampus after noise exposure and tinnitus induction in Guinea pigs
(John Wiley & Sons, Inc., 2019-08)
Here, we investigate remodeling of hippocampal cholinergic inputs after noise exposure and determine the relevance of these changes to tinnitus. To assess the effects of noise exposure on the hippocampus, guinea pigs were ...
Overview of Gene Targeting by Homologous Recombination
(Wiley Periodicals, Inc., 2007-07)
The analysis of mutant organisms and cell lines is important in determining the function of specific proteins. Recent technological advances in gene targeting by homologous recombination in mammalian systems enable the ...
Methanol exposure interferes with morphological cell movements in the Drosophila embryo and causes increased apoptosis in the CNS
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-05)
Despite the significant contributions of tissue culture and bacterial models to toxicology, whole animal models for developmental neurotoxins are limited in availability and ease of experimentation. Because Drosophila ...
Assessing methylphenidate preference in ADHD patients using a choice procedure
(Springer-Verlag, 2004-10)
Methylphenidate (MPH) is widely used in the treatment of attention deficit hyperactivity disorder (ADHD) and is associated with positive clinical effects across a wide range of domains. Despite the clinical effectiveness ...
Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers
(Springer-Verlag; Springer-Verlag Wien, 2002-10)
Meta-hydroxyephedrine (HED) comprises four stereoisomers consisting of two enantiomeric pairs related to ephedrine and pseudoephedrine. HED is transported into adrenergic neurons and radiolabeled HED has been employed in ...
NF-ΚB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity
(Wiley Subscription Services, Inc., A Wiley Company, 2005-03-01)
Cell death in outer hair cells of the mammalian inner ear induced by aminoglycoside antibiotics is mediated by reactive oxygen species (ROS) and can be prevented by antioxidants. The current study investigates the role of ...