Now showing items 1-10 of 65
Self-Encapsulation of Vaccine Antigens in PLGA Microparticles and Microneedles.
(2016)
There is an urgent need to reduce reliance on hypodermic injections for many protein-based therapies. Alternative approaches include developing controlled release formulations, which reduce dosing frequencies, and utilizing ...
Effect of Glycolipid Incorporation on Liposome Uptake by Antigen-Presenting Cells.
(2016)
Robust cell-mediated immune responses are considered vital for successful vaccination against intracellular pathogens and cancer. Enhancing antigen uptake by dendritic cells (DCs) is a proposed way to stimulate cell-mediated ...
Antiretroviral Therapy: New Mechanistic and Therapeutic Insights for HIV Single-Entity and Combination Drug Products.
(2015)
With approximately 39 million people having died from AIDS-related causes so far, HIV is the world’s leading infectious killer. The large majority of the 35 million people currently living with the virus reside in ...
An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri
(2016)
Shigella flexneri is a gram-negative enteropathogen that infects the human colonic epithelium. It is estimated that Shigella spp. infect 165 million people a year worldwide. Symptoms of shigellosis include bloody dysentery, ...
Tumor Necrosis Factor-Regulated Granuloma Formation in Tuberculosis: Multi-Scale Modeling and Experiments.
(2012)
Tuberculosis is a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb). Multiple immune factors control host responses to Mtb infection, including the formation of granulomas in the lung, which are aggregates ...
Voltage-gated Na+ Channels: Not Just for Conduction.
(2016)
Voltage-gated sodium channels (VGSCs), composed of a pore-forming alpha subunit and up to two associated Beta subunits, are critical for the initiation of the action potential in excitable tissues. VGSC Beta subunits, first ...
Characterization of Flagellin-Functionalized Liposomes as a Vaccine Carrier and Adjuvant.
(2015)
Since the recognition that the adjuvant capacity of flagellin is better harnessed when both flagellin and the antigen are delivered to the same cell, there has been a need to exploit flagellin in ways that fulfill this ...
The Epigenetic Regulation of KCNA5 in Pediatric Solid Tumors and its Role in Cancer Biology.
(2015)
Regulation of intracellular elemental ion levels is essential for normal cellular homeostasis. Regulation of potassium ion flux impacts many biological processes, such as proliferation and cell survival, therefore it is ...
Mechanistic Analysis of In Vitro and In Vivo Drug Release from PLGA Microspheres.
(2015)
Poly (lactic-co-glycolic) acid (PLGA) microspheres have been extensively studied for controlled drug delivery, and more than a dozen PLGA formulations are currently on the market. However, surprisingly little information ...
Development, Characterization and Application of a Novel Mouse Line Humanized for the Intestinal Peptide Transporter PepT1.
(2015)
Transporter PepT1 is abundantly expressed on the apical side of small intestinal enterocytes and has major responsibility for the intestinal absorption of peptides and peptide-like drugs with a significant species difference ...