Now showing items 21-30 of 65
Discovery and Development of Small Molecule Probes for the SUMO protease SENP1, a Novel Target for Advanced Prostate Cancer Therapy
(2017)
Androgen signaling through the androgen receptor (AR) is essential for normal growth and function of the prostate gland. In prostate cancer (PC), androgens provide the main proliferative drive for the disease, making ...
Cocaine Esterase: A pharmacokinetic approach to treating cocaine addiction
(2017)
Cocaine’s impact on society spans several thousand years, yet its adverse effects due to the toll of addiction have only imposed a global problem during the last hundred years. After cocaine was isolated from its natural ...
Targeting DNA Damage, Apoptosis, and the Cell Cycle for the Radiosensitization of Aggressive Forms of Breast Cancer
(2022)
Breast cancer is the most common invasive cancer diagnosed in women, and there is a critical need to identify novel treatment strategies. To that end, therapies designed to target molecular drivers specific to individual ...
Functional Analysis of Protein S-Palmitoylation Enzymes.
(2015)
Protein S-palmitoylation is a dynamic, hydrophobic, post-translational modification of cysteine residues that is required for the spatiotemporal organization of hundreds of proteins. In turn, protein palmitoylation contributes ...
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...
Development of Novel Small Molecule Inhibitors of Neurotropic Alphavirus Replication.
(2014)
Emerging mosquito-borne viruses (arboviruses) constitute a large public health risk because of the ubiquity of mosquitoes and the potential for mosquito-human transmission. Neurotropic alphaviruses are of particular interest ...
Delineating the Specificity of Cannabinoid Effects by Investigating Cannabinoid Receptor-1 Trafficking and Signaling
(2022)
Pharmaceuticals target specific proteins within the body to produce desired therapeutic outcomes, and the G-protein-coupled receptor (GPCR) family represents the most common type of pharmaceutical target. Traditional models ...
Design, Synthesis, and Evaluation of Novel, Multifunctional Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics
(2019)
The opioid receptors modulate a wide variety of physiological and behavioral functions, including pain, mood, and reward. There are three main types of opioid receptors – kappa (KOR), mu (MOR), and delta (DOR), and many ...
Investigating the Role of Protein Kinase C Inhibitors in Amphetamine-Mediated Behaviors
(2019)
Amphetamines (AMPH) are among the most widely misused drugs in the United States and worldwide. Currently, there are no pharmacological interventions for amphetamine-use disorder. A close examination of mechanism of action ...
Characterization of the Intestinal Permeability and Oral Absorption of Valacyclovir in Wildtype and huPepT1 Transgenic Mice
(2019)
PepT1 (SLC15A1) is a transporter apically expressed along the epithelial cells of the gastrointestinal tract and is responsible for the absorption of di/tripeptides, ACE inhibitors, β-lactam antibiotics and numerous prodrugs. ...