Now showing items 31-40 of 65
In Vitro and In Vivo Testing of Ultra-Small Gold Nanoparticles as a Novel Drug Delivery Platform for Enhancing the Brain Penetration and Receptor Binding Affiinity of Central Nervous System Drugs.
(2013)
The endothelial cells of brain capillaries form the so-called blood brain barrier (BBB) which protects the central nervous system (CNS) from the entry of neurotoxins and blood components. Consequently, more than 98% of ...
Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases
(2016)
Kinases play a crucial role in a variety of cell signaling pathways that control processes such as: growth, motility, and angiogenesis. Not surprisingly, dysregulation of proper kinase signaling often leads to cancer. Since ...
PLGA Depots for Controlled Release of Bevacizumab.
(2016)
The advent of monoclonal antibody (mAb)-based anti-vascular endothelial growth factor (VEGF) therapy for treatment of wet age-related macular degeneration (AMD) has significantly improved the clinical outcomes in patients. ...
Mechanisms and Engineering of Polymeric Nanoparticles for Modulating Innate and Adaptive Immune Responses
(2019)
The delivery of disease-relevant antigens by nanoparticles is a promising strategy for selectively inhibiting pathogenic autoreactive cells while maintaining a protective immune repertoire. This process, known as ...
The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking.
(2013)
Opioids are widely used in the treatment of pain; however, the development of tolerance and dependence limit clinical use. The co-administration of a µ opioid receptor (MOR) agonist with a δ opioid receptor (DOR) agonist ...
Advances in in Vivo Neurochemical Monitoring Using Microdialysis with Liquid Chromatography-Mass Spectrometry
(2020)
Improving our understanding of the central nervous system necessitates developing techniques capable of making neurochemical measurements in the complex extracellular environment of the brain within living animal models. ...
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.
(2014)
Alzheimer’s disease (AD) places a significant and dramatically increasing burden on society. While pathological hallmarks of this neurodegenerative disorder are known, the exact cause remains unclear. Acetylcholinesterase ...
The Pharmacoepigenomics Informatics Pipeline and H-GREEN Hi-C Compiler: Discovering Pharmacogenomic Variants and Pathways with the Epigenome and Spatial Genome
(2018)
Over the last decade, biomedical science has been transformed by the epigenome and spatial genome, but the discipline of pharmacogenomics, the study of the genetic underpinnings of pharmacological phenotypes like drug ...
Mechanisms and Modeling of the Intestinal Absorption, Activation, and Systemic Availability of Gemcitabine and a Gemcitabine Prodrug for Oral Administration
(2020)
Gemcitabine (2’-2’-difluoro-deoxycytidine) is an intravenously administered nucleoside analogue used in the treatment of various solid tumor cancers. While oral gemcitabine administration would offer a more patient-friendly, ...
Membrane Curvature During Cell Migration
(2020)
Biological membranes serve as a physical barrier of cell and organelles. In addition, as biological membranes house numerous proteins, they also act as signaling hubs involved in the regulation of a wide array of cellular ...