Now showing items 61-65 of 65
The Role of Sulfenic Acid Modification in the Regulation of the Cardiovascular Voltage-Gated Potassium Channel, Kv1.5.
(2011)
Atrial fibrillation, the most common cardiac arrhythmia in the United States, is a significant cause of morbidity and mortality. Environmental exposures such as cigarette smoking, as well as pre-existing cardiovascular ...
Hypocretin-1 and GABA in the Pontine Reticular Formation Interact to Promote Wakefulness.
(2010)
Hypocretin-1 and hypocretin-2 are wake-promoting neuropeptides that are exclusively synthesized in the lateral hypothalamus. Hypocretin deficiency underlies the sleep disorder narcolepsy, which is characterized by excessive ...
Thermodynamic and Kinetic Parameters that Explain Crystallization and Solubility of Pharmaceutical Cocyrstals.
(2009)
Cocrystals have emerged as a viable alternative to increase the diversity of solid-state drug forms. Literature surrounding cocrystals range from design using crystal engineering principles to evaluating the pharmaceutical ...
A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development.
(2011)
Predicting and controlling the systemic and local pharmacokinetics of pulmonary medications in different regions of the lung is critical for optimizing the efficacy and safety of inhaled drugs. Here, a modular, multiscale, ...
Cheminformatic and Mechanistic Study of Drug Subcellular Transport/Distribution.
(2011)
The subcellular transport and distribution behavior determines both the pharmacological effect on the cellular level and the drug exposure at a tissue, organ and whole body level. Despite of the rapid evolution in experimental ...