Now showing items 81-90 of 209
Current benzodiazepine issues
(Springer-Verlag, 1995-03)
This article deals with some of the recent evidence bearing on the issues of the liability of benzodiazepines to lead to abuse, dependence, and adverse behavioral effects. Reviews of epidemiological, clinical and experimental ...
The effects of scopolamine hydrobromide on one-way and two-way avoidance learning in rats
(Elsevier, 1968-09)
Previous studies have shown certain striking similarities between the behavioral effects produced by some anticholinergic drugs and the effects produced by hippocampal destruction. To investigate this parallel more thoroughly, ...
Y-Maze behavior after an analog of ACTH 4-9, evidence for an attentional alteration
(Springer-Verlag, 1980-11)
Adult, male, Swiss-Webster mice were injected with either control solution or various doses of a long-acting analog of ACTH 4-9. The drug produced significant alterations in performance in an equiangular Y-maze. In comparison ...
Species differences in the eeg response to epinephrine, 5-hydroxytryptamine and nicotine in brainstem transected animals,
(Elsevier, 1963-06)
Species differences have been observed in the EEG activation response to intravenous epinephrine, 5-hydroxytryptamine, and nicotine in rabbits, cats, dogs and monkeys. It was also found that a relatively high level of ...
Self-administration of methohexital, midazolam and ethanol: effects on the pituitary–adrenal axis in rhesus monkeys
(Springer-Verlag, 2005-02)
There is disagreement in the literature with respect to how drugs of abuse affect the functioning of the hypothalamic–pituitary–adrenal (HPA) axis, and whether these changes in endocrine function may be related to the ...
Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
(Springer-Verlag, 2006-04)
Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have suggested similar effects and correlated motor and cognitive ...
Pargyline-induced increases in sensitivity to the effects of drugs on operant behavior in pigeons
(Springer-Verlag, 1977-01)
Pigeons responded under a multiple fixedinterval 5-min, 30-response fixed-ratio schedule of food reinforcement. Acute pargyline doses between 10.0 and 50.0 mg/kg (i.m.), given immediately prior to the session, decreased ...
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serontonergic involvement
(Springer-Verlag, 2002-06)
Rationale: The reinforcing effects of MDMA and its enantiomers have not been extensively characterized in laboratory animals. Objectives: To investigate whether MDMA and its stereoisomers would be self-administered ...
Psychomotor stimulant self administration as a function of dosage per injection in the Rhesus monkey
(Springer-Verlag, 1971-09)
The relationships between drug dosage per injection and response rate, and drug dosage per injection and total daily drug intake were ascertained in Rhesus monkeys which self-administered cocaine, pipradrol, methylphenidate ...
The effects of stimulants and depressants on cocaine self-administration behavior in the Rhesus monkey
(Springer-Verlag, 1973-12)
The effects of acute intramuscular pretreatment with several dosages of a variety of centrally acting compounds on intravenous cocaine self-administration behavior were ascertained. Pretreatment with morphine and pentobarbital ...