Now showing items 1-10 of 492
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
Stress induced grooming in the rat -- An endorphin mediated syndrome
(Elsevier, 1979-07)
Exposure of adult male Sprague--Dawley rats to a non-traumatic noise-light stress procedure subsequently increased grooming behavior in a novel environment. The grooming syndrome was marginally facilitated by adrenalectomy ...
A VIP-like peptide co-occurs with substance P and enkephalin in cholinergic preganglionic terminals of the avian ciliary ganglion
(Elsevier, 1987-07-09)
Using single-label and double-label immunohistochemical techniques, many of the substance P-enkephalin containing preganglionic terminals of the avian ciliary ganglion were found to also contain a VIP-like peptide. Since ...
The effect of limbic damage on the retention and performance of a runway response
(Elsevier, 1966-07)
Rats were trained to run a linear runway while hungry for food. Then they were tested for retention, continued performance levels, and extinction after recovery from bilateral damage of the hippocampus, the septal area, ...
The temporal structure of motivation: III. Identification and ecological significance of ultradian rhythms of intracranial reinforcement
(Elsevier, 1980-10)
Adult male Sprague-Dawley rats were stereotactically implanted with intracranial electrodes aimed at the anterior medial forebrain bundle, and trained to self-administer intracranial stimulation. Following 3 weeks of ...
Effect of Neuropeptide Y on Natural Killer Activity of Normal Human Lymphocytes
(Elsevier, 1993-03)
The in vitro effect of neuropeptide Y (NPY) on natural killer (NK) cell activities of normal lymphocytes was investigated. NPY at 10-9 to 10-12M concentrations produced significant suppression of NK activity against K 562 ...
A dual function activity-dependent, muscle-specific enhancer from rat nicotinic acetylcholine receptor δ-subunit gene
(John Wiley & Sons, Inc., 1996-11)
Nicotinic acetylcholine receptors (nAChR) mediate communication between nerve and muscle. The expression of these receptors increases dramatically during muscle development when myoblasts are fusing into multinucleated ...
Deficit in active avoidance learning in rats following penicillin injection into hippocampus
(Elsevier, 1971-06)
Penicillin was found to cause epileptiform (spike) activity when injected into the hippocampus of male rats. Animals so prepared were found to be severely impaired in the acquisition of a two-way active avoidance task. ...
Muscarine-sensitive voltage-dependent potassium current in cultured murine spinal cord neurons
(Elsevier, 1983-01-31)
Muscarine produced membrane depolarization and decreased membrane conductance of mouse spinal cord neurons in dissociated cell culture. When the neurons were voltage clamped, muscarine evoked inward currents which increased ...
Receptor Binding Techniques
(Wiley Periodicals, Inc.Elsevier/North‐Holland Biomedical Press, 1997-09)
This overview first discusses issues relating to the selection of radioligand for receptor binding assays, including the isotopic label and considerations pertaining to the pharmacological and chemical profile of the ligand. ...