Now showing items 41181-41190 of 41556
A Neuron-Specific Histone Demethylase Complex Fine Tunes Neurodevelopment
(2022)
Cell-type specific transcriptional programs are thought to be defined by cell-type specific transcription factors (TFs) that bind to specific DNA sequences. In contrast, chromatin regulators are ubiquitously expressed and ...
Droplet Microfluidics Coupled to Capillary Electrophoresis and Mass Spectrometry for Pharmacological Applications
(2022)
Modern drug discovery relies on high-throughput screening for lead generation and protein target evaluation. There is a critical need to develop assays that not only have large-scale screening capabilities but provide ...
Low Temperature Electrodeposition of Epitaxial Silicon Thin Films
(2022)
This thesis explores the applicability of Si electrodeposition to the synthesis of crystalline Si at low temperatures. Electrodeposition has been long perceived as an ideal route for the synthesis of semiconductor materials ...
Joint Use of Far-Infrared and Mid-Infrared Observation for Sounding Retrievals: Learning From the Past for Upcoming Far-Infrared Missions
(WORLD SCIENTIFICWiley Periodicals, Inc., 2023-03)
Atmosphere and surface properties are routinely retrieved from satellite measurements and extensively used in weather forecast and climate analysis. Satellite missions dedicated to fill the gap of far-infrared (far-IR) ...
Simulating the Transport and Rupture of Pollen in the Atmosphere
(Cambridge University PressWiley Periodicals, Inc., 2023-03)
Pollen, one type of primary biological aerosol particle (PBAP), is emitted from the terrestrial biosphere and can undergo physical changes in the atmosphere via particle rupture. To examine the fate of pollen and its ...
Development and Mechanistic Elucidation of Carbonyl-Olefin Metathesis Transformations
(2022)
Olefin–olefin metathesis has drastically changed how olefins are synthesized in materials, agrochemicals, and pharmaceuticals. An important variation of olefin–olefin metathesis is carbonyl–olefin metathesis, which provides ...
Doped Cobalt Oxide Catalysts for Aqueous, Electrochemical Oxygen Evolution and Alcohol Oxidation
(2022)
As global energy production transitions to more renewable yet intermittent sources such as solar and wind, long term storage of this energy is a critical challenge that needs to be overcome. Hydrogen gas produced through ...
A Bidentate Ligand Featuring Ditopic Lewis Acids in the Second Sphere for Selective Substrate Capture and Activation
(Wiley Periodicals, Inc., 2023-03-20)
We present a ligand platform featuring appended ditopic Lewis acids to facilitate capture/activation of diatomic substrates. We show that incorporation of two 9-borabicyclo[3.3.1]nonane (9-BBN) units on a single carbon ...
Understanding the Mechanism of Disaggregation and Unfolding of the hsp100 Family Through cryo-EM Structure Determination
(2022)
Proteins in the cell can become misfolded, leading to toxic aggregates. These toxic aggregates, which can increase during cellular stress and aging, are hallmarks of many neurodegenerative diseases, including Alzheimer’s ...
Structure and Targeting of Precursor MicroRNA-31: From Mechanism to Application
(2024)
As an essential post-transcriptional regulator of gene expression, microRNA (miRNA) levels must be strictly maintained. The biogenesis of many miRNAs is regulated by trans-acting protein partners, which exert control through ...