Now showing items 21-27 of 27
Understanding Pre-mRNA Dynamics in Single Spliceosome Complexes.
(2013)
The spliceosome is a large RNA-protein complex that catalyzes pre-mRNA splicing by removing sequences called introns and joining of the remaining sequences, called exons, to produce a mature mRNA. Despite over a quarter ...
Interactions Between Fluorescent Molecules and Plasmonic Nanoparticles: A Super-Resolution Study
(2017)
Single-molecule super-resolution imaging techniques play an increasingly important role in studying complex fine structures, dynamics and interactions in nanoscale confined spaces. The resolution of this technique can be ...
Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone.
(2013)
Damm et al. utilized a multiple protein structure (MPS)-based method and discovery an allosteric site of HIV-1 protease (HIV-1p) that had not been described before. Based on this new site, a MPS-based pharmacophore model ...
Specialized Metabolites and Related Biosynthetic Enzymes in Tomato Glandular Trichomes: Defining Biological Functions of Specific Gland Types.
(2011)
Trichomes are tiny appendages that grow out from the surfaces of leaves, stems, flowers, and other above-ground parts of many plants. They contribute to important biological functions such as determent of herbivores, ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...
Characterization of the Dynamic Interactions of Transcriptional Activators
(2010)
Transcription is initiated through a series of coupled binding equilibria between transcriptional activators and their array of protein targets within the transcriptional machinery. However, previous efforts to kinetically ...