Now showing items 31-39 of 39
The Role of Collagen Cross-linking in Craniofacial and Long Bone Mineralization and Healing
(2021)
Compromised collagen and mineral can lead to decreases in bone quantity and quality in a variety of diseases that differentially affect craniofacial and long bones. Since bone is a composite - with mineral lending stiffness ...
Development Of An Artificial Membrane Lung
(2016)
End-stage lung disease due to chronic obstructive pulmonary disease (COPD) is a leading cause of death across the world. However, treatment options for end-stage COPD are extremely limited. An artificial membrane lung ...
Engineering Platforms for Mimicking Cellular Processes using Cell-Free Expression Systems
(2020)
Bottom-up in vitro reconstitution has provided fundamental insights into the mechanisms of key cellular processes. Traditional reconstitution methods rely on protein purification as the primary means of extracting functional ...
On the Phenotype of White-tailed Deer Antlerogenic Progenitor Cells.
(2013)
Repair of large bone defects is one of the key unmet clinical needs in musculoskeletal medicine. A rare exception to the limits of mammalian regeneration is the deer antler, the only example of complete, repeated organ ...
Continuous Microfluidic Viscometers for Biochemical and Diagnostic Analysis
(2017)
Microfluidic technologies have advanced rapidly over the past two decades. Numerous microfluidic devices to assess different biomarkers have been reported, yet very few address physical properties, such as viscosities, of ...
To Be, or Not to Be: Cellular Homeostasis to Mechanical Perturbations
(2016)
Mechanical homeostasis is an emerging mechanobiology concept that describes the critical biological process to maintain whole-cell/tissue physiology against forces and deformation arising both intra- and extracellularly. ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction.
(2009)
The calculation of physicochemical and biological properties is essential in order to facilitate modern drug discovery. Chemical spaces dimensionalized by these descriptors have been used to scaffold-hop in order to discover ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...