Now showing items 21-30 of 111
Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest Α9-like receptors
(John Wiley & Sons, Inc., 2001-02-01)
The medial efferent system innervates outer hair cells in the organ of Corti. Neurotransmission at this synapse is mediated by acetylcholine (ACh) acting on nicotinic ACh receptors containing the Α9 subunit. In addition ...
Proportional myoelectric control of a virtual object to investigate human efferent control
(Springer-Verlag, 2004-12)
We used proportional myoelectric control of a one-dimensional virtual object to investigate differences in efferent control between the proximal and distal muscles of the upper limbs. Eleven subjects placed one of their ...
Overview of Gene Targeting by Homologous Recombination
(Wiley Periodicals, Inc., 2002-10)
Overview of Gene Targeting by Homologous Recombination (Richard Mortensen, University of Michigan Medical School, Ann Arbor, Michigan).This overview describes the basic methodology and applications of homologous recombination. ...
Tracking Quantum Dot–Tagged Calcium Channels at Vertebrate Photoreceptor Synapses: Retinal Slices and Dissociated Cells
(Wiley Periodicals, Inc., 2013-01)
At synapses in the central nervous system, precisely localized assemblies of presynaptic proteins, neurotransmitter‐filled vesicles, and postsynaptic receptors are required to communicate messages between neurons. Our ...
Analyzing Binding Data
(Academic PressWiley Periodicals, Inc., 2010-07)
Measuring the rate and extent of radioligand binding provides information on the number of binding sites, and their affinity and accessibility of these binding sites for various drugs. This unit explains how to design and ...
Overview of Gene Targeting by Homologous Recombination
(Wiley Periodicals, Inc., 2007-07)
The analysis of mutant organisms and cell lines is important in determining the function of specific proteins. Recent technological advances in gene targeting by homologous recombination in mammalian systems enable the ...
Methanol exposure interferes with morphological cell movements in the Drosophila embryo and causes increased apoptosis in the CNS
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-05)
Despite the significant contributions of tissue culture and bacterial models to toxicology, whole animal models for developmental neurotoxins are limited in availability and ease of experimentation. Because Drosophila ...
Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers
(Springer-Verlag; Springer-Verlag Wien, 2002-10)
Meta-hydroxyephedrine (HED) comprises four stereoisomers consisting of two enantiomeric pairs related to ephedrine and pseudoephedrine. HED is transported into adrenergic neurons and radiolabeled HED has been employed in ...
NF-ΚB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity
(Wiley Subscription Services, Inc., A Wiley Company, 2005-03-01)
Cell death in outer hair cells of the mammalian inner ear induced by aminoglycoside antibiotics is mediated by reactive oxygen species (ROS) and can be prevented by antioxidants. The current study investigates the role of ...
Regulation of Myo-Inositol Homeostasis in Differentiated Human NT2-N Neurons
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-05)
We have investigated the possible role of second messengers on inositol homeostasis in NT2-N cells, human central nervous system neurons obtained by terminal differentiation of teratocarcinoma precursors. Uptake of inositol ...