Now showing items 121-130 of 639
Overview of Gene Targeting by Homologous Recombination
(Wiley Periodicals, Inc., 2007-07)
The analysis of mutant organisms and cell lines is important in determining the function of specific proteins. Recent technological advances in gene targeting by homologous recombination in mammalian systems enable the ...
Methanol exposure interferes with morphological cell movements in the Drosophila embryo and causes increased apoptosis in the CNS
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-05)
Despite the significant contributions of tissue culture and bacterial models to toxicology, whole animal models for developmental neurotoxins are limited in availability and ease of experimentation. Because Drosophila ...
A global logrank test for adaptive treatment strategies based on observational studies
(American Psychiatric Publishing, IncWiley Periodicals, Inc., 2014-02-28)
Baseline patient characteristics and mortality associated with longitudinal intervention compliance
(John Wiley & Sons, Ltd., 2007-12-10)
Lin et al. ( http://www.biostatsresearch.com/upennbiostat/papers/ , 2006) proposed a nested Markov compliance class model in the Imbens and Rubin compliance class model framework to account for time-varying subject ...
Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers
(Springer-Verlag; Springer-Verlag Wien, 2002-10)
Meta-hydroxyephedrine (HED) comprises four stereoisomers consisting of two enantiomeric pairs related to ephedrine and pseudoephedrine. HED is transported into adrenergic neurons and radiolabeled HED has been employed in ...
NF-ΚB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity
(Wiley Subscription Services, Inc., A Wiley Company, 2005-03-01)
Cell death in outer hair cells of the mammalian inner ear induced by aminoglycoside antibiotics is mediated by reactive oxygen species (ROS) and can be prevented by antioxidants. The current study investigates the role of ...
Did Unexpectedly Strong Economic Growth Cause the Oil Price Shock of 2003–2008?
(Wiley Periodicals, Inc.MIT Press, 2013-08)
Recently developed structural models of the global crude oil market imply that the surge in the real price of oil between mid 2003 and mid 2008 was driven by repeated positive shocks to the demand for all industrial ...
Regulation of Myo-Inositol Homeostasis in Differentiated Human NT2-N Neurons
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-05)
We have investigated the possible role of second messengers on inositol homeostasis in NT2-N cells, human central nervous system neurons obtained by terminal differentiation of teratocarcinoma precursors. Uptake of inositol ...
A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss
(Wiley Subscription Services, Inc., A Wiley Company, 2006)
Acoustic overstimulation induces calcium overload and activation of mitochondria-mediated cell death pathways in outer hair cells (OHC) of the cochlea. However, it is not known whether these events are interrelated or ...
Hydrologic and biogeochemical controls on the spatial and temporal patterns of nitrogen and phosphorus in the Kuparuk River, arctic Alaska
(John Wiley & Sons, Ltd., 2008-08-15)
Nitrogen (N) and phosphorus (P) dynamics in the Kuparuk River in arctic Alaska were characterized in a 3-year study using routine samples near the mouth of the river at the Arctic Ocean, synoptic whole-river surveys, and ...