Now showing items 1-10 of 4257
β-funaltrexamine antagonizes the discriminative stimulus effects of morphine but not naltrexone in pigeons
Antagonistic actions of the irreversible, μ-selective antagonist β-funaltrexamine (β-FNA) were evaluated in pigeons trained to discriminate among intramuscular injections of morphine (5.6 mg/kg), saline, and naltrexone ...
A Geometric Framework for Evaluating Rare Variant Tests of Association
(Wiley Periodicals, Inc., 2013-05)
The wave of next‐generation sequencing data has arrived. However, many questions still remain about how to best analyze sequence data, particularly the contribution of rare genetic variants to human disease. Numerous ...
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
Synthetic Strategies and Parameters Involved in the Synthesis of Oligodeoxyribonucleotides According to the Phosphoramidite Method
(Wiley Periodicals, Inc.Plenum, 2000-02)
The phosphoramidite approach has had a major impact on the synthesis of oligonucleotides. This unit describes parameters that affect the performance of this method for preparing oligodeoxyribonucleotides, as well as a ...
Palmitoylation of the luteinizing hormone/human chorionic gonadotropin receptor regulates receptor interaction with the arrestin-mediated internalization pathway
(Blackwell Science Ltd, 2001-03-15)
Mechanism and Specificity of Human DNA Ligase I
Cellular DNA replication and repair pathways conclude with faithful rejoining of broken phosphodiester bonds by DNA ligases. Therefore, a thorough dissection of the molecular underpinnings of DNA ligation is crucial to a ...
The direct enhancement of positive palatability by chlordiazepoxide is antagonized by Ro 15-1788 and CGS 8216
In a pre previous study, it was found that positive, palatability-dependent consummatory reactions in rats to intraorally infused tastes were facilitated by chlordiazepoxide (10 mg/kg). In contrast, the rats' more neutral ...
Scribble Subcellular Localization Modulates Recruitment of Distinct YES1 Conformations to Regulate YAP Phosphorylation
The multi-domain scaffolding protein Scribble regulates cell polarity and growth signaling at cell-cell junctions. In epithelial cancers, its mislocalization and overexpression paradoxically transforms Scribble from a tumor ...
Ion beam modification of metals: Compositional and microstructural changes
Ion implantation has become a highly developed tool for modifying the structure and properties of metals and alloys. In addition to direct implantation, a variety of other ion beam techniques such as ion beam mixing, ion ...
Compartmentalized Photoreactions within Compositionally Anisotropic Janus Microstructures
(WILEY-VCH Verlag, 2011-03-02)
We demonstrate spatially controlled photoreactions within bicompartmental microparticles and microfibers. Selective photoreactions are achieved by anisotropic incorporation of photocrosslinkable poly(vinyl cinnamate) in ...