Now showing items 1-10 of 16
Determination of plasma trimetrexate levels using gas chromatography--mass spectrometry with selected-ion monitoring
(Elsevier, 1986)
Trimetrexate is a potent inhibitor of dihydrofolate reductase and has demonstrated significant antitumor activity against murine and human cell lines both in vitro and against several murine transplanted tumors. The ...
Simultaneous determination of thymine and 5-bromouracil in DNA hydrolysates using gas chromatography--mass spectrometry with selected-ion monitoring
(Elsevier, 1986)
The gas chromatographic--mass spectrometric method using selected-ion monitoring (GC--MS--SIM) described here quantitatively determines the amount of DNA thymine replacement by 5-bromouracil (BU) after exposure to ...
5-bromo-2'-deoxyuridine incorporation into DNA in hepatic VX2 tumor-bearing rabbits,
(Elsevier, 1989-08)
The halogenated pyrimidine 5-bromo-2'-deoxyuridine (BrdUrd) possesses both radiosensitizing and antimetabolite effects through its incorporation as a thymidine analog in replicating DNA. To evaluate the regional advantage ...
Analysis of bromodeoxyuridine incorporation into DNA: Comparison of gas chromatographic/mass spectrometric, CsCl gradient sedimentation, and specific radioactivity methods
(Elsevier, 1987-02-15)
A sensitive new method for the quantitation of 5-bromodeoxyuridine (BrdUrd) incorporated into DNA by GC/MS analysis of enzymatically released Thy and bromouracil (BrUra) is presented. The hydrolysis procedure was characterized ...
Hepatic arterial chemotherapy for primary and metastatic liver cancers
(Springer-Verlag, 1989-01)
Hepatic arterial chemotherapy represents a means of selectively exposing hepatic tumor to cytotoxic agents. Although 5-fluoro-2′-deoxyuridine has been shown to generate a higher response rate in the treatment of colorectal ...
Response of human HT-29 colorectal tumor cells to extended exposure to bromodeoxyuridine
(Springer-Verlag, 1989-01)
Effects of the extended exposure of a human colorectal tumor-cell line (HT-29) to bromodeoxyuridine (BrdUrd) were studied in anticipation of the clinical use of that agent to treat colorectal cancer, particularly as a ...
Pharmacologic studies on the dibutyl and γ-monobutyl esters of methotrexate in the rhesus monkey
(Springer-Verlag, 1982-12)
The pharmacokinetics and metabolism of dibutyl methotrexate (DBMTX) and γ-monobutyl methotrexate (γ-MBMTX) were studied in Rhesus monkeys. When a bolus IV dose of either [ 3 H]DBMTX or [ 3 H]γ-MBMTX was given, the principal ...
Dynamics of Bromodeoxyuridine Incorporation into DNA of Squamous Carcinoma Cells During Mid and Late Logarithmic Growth
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1988-08)
Head and neck squamous carcinoma cell lines, UM-SCC 1, 5, 9, 11B, and 14B, were exposed in vitro to bromodeoxyuridine (BUdR) during logarithmic growth to determine the effects of drug concentration (0.01 to 10 µ M ) and ...