Now showing items 1-10 of 812
A Geometric Framework for Evaluating Rare Variant Tests of Association
(Wiley Periodicals, Inc., 2013-05)
The wave of next‐generation sequencing data has arrived. However, many questions still remain about how to best analyze sequence data, particularly the contribution of rare genetic variants to human disease. Numerous ...
Survival following salvage therapy for primary refractory peripheral T‐cell lymphomas (PTCL)
(Wiley Periodicals, Inc.American Society of Hematology, 2018-03)
Optimal salvage therapy for primary refractory peripheral T‐cell lymphomas (PTCL) and the role of hematopoietic stem cell transplant (SCT) remain poorly defined. We conducted a retrospective review of clinical outcomes and ...
Genomic evidence for elevated mutation rates in highly expressed genes
(John Wiley & Sons, Ltd, 2012-12)
Lumbar Vertebral Body Bone Microstructural Scaling in Small to Medium‐Sized Strepsirhines
(Wiley Subscription Services, Inc., A Wiley Company, 2013-02)
Bone mass, architecture, and tissue mineral density contribute to bone strength. As body mass (BM) increases any one or combination of these properties could change to maintain structural integrity. To better understand ...
A GAIN in understanding autoproteolytic G protein‐coupled receptors and polycystic kidney disease proteins
(John Wiley & Sons, Ltd, 2012-03-21)
Ontogenetic relationships between cranium and mandible in coyotes and hyenas
(Wiley Subscription Services, Inc., A Wiley Company, 2011-06)
Developing animals must resolve the conflicting demands of survival and growth, ensuring that they can function as infants or juveniles while developing toward their adult form. In the case of the mammalian skull, the ...
Computational analysis of unassigned high-quality MS/MS spectra in proteomic data sets
(WILEY-VCH Verlag, 2010-07)
In a typical shotgun proteomics experiment, a significant number of high-quality MS/MS spectra remain “unassigned.” The main focus of this work is to improve our understanding of various sources of unassigned high-quality ...
Thyroid Hormone Modulation of DNA Methylation in the Developing Brain.
(2015)
Postembryonic brain development is dependent on thyroid hormone (T3). The actions of T3 are mediated by T3 receptors (TRs) that bind T3 response elements (T3REs) in the genome and regulate gene transcription through ...
A comparative prospective observational study of children and adults with immune thrombocytopenia: 2‐year follow‐up
(Lippincott Williams & WilkinsWiley Periodicals, Inc., 2018-06)
Comparative clinical studies of children and adults with immune thrombocytopenia (ITP) are poorly covered in the literature. However, the accepted classification of ITP—childhood ITP and adult ITP—results in considerable ...