Now showing items 1-10 of 43
Effect of Neuropeptide Y on Natural Killer Activity of Normal Human Lymphocytes
(Elsevier, 1993-03)
The in vitro effect of neuropeptide Y (NPY) on natural killer (NK) cell activities of normal lymphocytes was investigated. NPY at 10-9 to 10-12M concentrations produced significant suppression of NK activity against K 562 ...
Synthesis of normal and variant human hypoxanthine-guanine phosphoribosyltransferase in Escherichia coli
(Elsevier, 1993-01-30)
Naturally occurring mutations in hypoxanthine-guanine phosphoribosyltransferase (HPRT) have been identified by amino acid sequencing, cDNA cloning, and direct nucleotide sequencing of PCR-amplified transcripts. To determine ...
Short-Term Adrenalectomy Increases Glucocorticoid and Mineralocorticoid Receptor mRNA in Selective Areas of the Developing Hippocampus
(Elsevier, 1993-10)
In the central nervous system, adrenal steroids bind to two different types of corticosteroid receptors: glucocorticoid (GR) or mineralocorticoid (MR). In vitro biochemical and autoradiographic techniques have been used ...
Characterization of the genes encoding carbonic anhydrase I of chimpanzee and gorilla: comparative analysis of 5' flanking erythroid-specific promoter sequences
(Elsevier, 1993-09-15)
The genes encoding carbonic anhydrase I (CA I) have been characterized for chimpanzee (Pan troglodytes) and gorilla (Gorilla gorilla). In addition, 44 nucleotides (nt) at the 5' end of the noncoding first exon (exon la), ...
CSF somatostatin in Alzheimer's disease and major depression: Relationship to hypothalamic-pituitary-adrenal axis and clinical measures
(Elsevier, 1993)
Patients with Alzheimer's disease (AD) and major depression have been shown to have overlapping clinical symptoms and biological markers, including decreased concentrations of cerebrospinal fluid (CSF) somatostatin-like ...
mnd2: A New Mouse Model of Inherited Motor Neuron Disease
(Elsevier, 1993-06)
The autosomal recessive mutation mnd2 results in early onset motor neuron disease with rapidly progressive paralysis, severe muscle wasting, regression of thymus and spleen, and death before 40 days of age. mnd2 has been ...
The gustatory competence of the lingual epithelium requires neonatal innervation
(Elsevier, 1993-04-16)
The rat vallate papilla is bilaterally innervated by the IXth nerve whose axons are required for the normal development of its several hundred taste buds. Temporary denervation during the developmental sensitive period for ...
Molecular Characterization of the Murine Neural Retina Leucine Zipper Gene, Nrl
(Elsevier, 1993-11)
The NRL gene (D14S46E) is expressed in cells of human retina and encodes a putative DNA-binding protein of the leucine zipper family. Here we describe the analysis of the murine homolog of the NRL gene, Nrl. Various cDNAs ...
Human PCK1 Encoding Phosphoenolpyruvate Carboxykinase Is Located on Chromosome 20q13.2
(Elsevier, 1993-01)
Cytoplasmic liver phosphoenolpyruvate carboxykinase (GTP)(PEPCK) catalyzes a rate-limiting step in gluconeogenesis. Primers derived from the rat liver PEPCK sequence were used to amplify a portion of the human liver cDNA ...
Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6
(Elsevier, 1993-01)
A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S253. For the region spanned ...