Now showing items 1-10 of 82
High levels of non-activated receptors in glucocorticoid-sensitive S49wt mouse lymphoma cells incubated with dexamethasone
(Elsevier, 1994-10)
Upon agonist binding the heteromeric glucocorticoid receptor complex under goes a conformational change (receptor activation). This event involves the dissociation of a dimer of 90 kDa heat shock proteins. Whereas receptor ...
CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic acinar cell CCKA receptor
(Elsevier, 1994)
The ability of CCKA antagonists to inhibit full and partial CCK agonists of the rat pancreatic acinar cell CCKA receptor has been studied. When isolated rat pancreatic acini were superfused with CCK-8 (10 pM-1 nM) or CCK-4 ...
Selective inhibition by alcohol and cortisol of natural killer cell activity of lymphocytes from cord blood
(Elsevier, 1994-12)
1. 1. The immunosuppressive effects of drugs such as alcohol or hormones such as cortisol may be age-related. To test this hypothesis, the authors investigated the in vitro effects of ethanol (EtOH) and cortisol on Natural ...
Immunohistochemical localization of the mu opioid receptors
(Elsevier, 1994-11-10)
Using antibodies generated to the C-terminal 63 amino acids of the cloned rat mu receptor, the present study examines the distribution of the mu receptor-like immunoreactivity (li) in perfused rat brain sections. Generally, ...
Clocinnamox blocks only mu receptors irreversibly: Binding evidence
(Elsevier, 1994-11-10)
Effects of tobacco smoking on the topographic EEG I
(Elsevier, 1994-09)
1. 1. The EEG and cardiovascular effects of smoking tobacco cigarettes of varying nicotine content were studied in Japanese chronic tobacco smokers.2. 2. Thirteen female and fifteen male adult normal volunteers were recruited ...
A comparison of proteins and peptides as substrates for microsomal and solubilized oligosaccharyltransferase
(Elsevier, 1994-11)
A chemoenzymatic synthesis of homogeneous neoglycoproteins and glycopeptides was explored using oligosaccharyltransferase isolated from yeast. Neither the microsomal form nor the solubilized form of the enzyme catalyzed ...
Biological effects of a novel intestinal peptide -- inhibiting enterocytogenin on cultured 3T3 mouse fibroblasts and L5178Y mouse lymphoma cells
(Elsevier, 1994-05-05)
The effects of a new intestinal peptide, inhibiting enterocytogenin (IEG) derived from pig intestinal mucosa were studied in vitro on 3T3 mouse fibroblasts and L5178Y mouse lymphoma cell line. IEG caused considerable growth ...
Studies on morpholinosphingolipids: Potent inhibitors of glucosylceramide synthase
(Elsevier, 1994-04-25)
Synthetic 1-morpholino-1-deoxyceramides were designed to inhibit glucosylceramide synthase. The most potent inhibitor 2a possesses the unnatural R,R-configuration of D-threo-sphingosine.
Selective effect of alcohol on cellular immune responses of lymphocytes from AIDS patients
(Elsevier, 1994)
In this study we examined the in vitro effects of alcohol on the proliferative responses of lymphocytes from healthy donors and AIDS patients to a recombinant fusion peptide, env-gag, corresponding to portions of the gp ...