Now showing items 1-10 of 37
Protein tyrosine phosphatases: characterization of extracellular and intracellular domains
(Elsevier, 1994-02)
Protein tyrosine phosphatases (PTPs) play an important role in the regulation of cell growth and differentiation. With over 30 PTPs identified, the specific functions of these enzymes are now being addressed. The identification ...
Nucleotide Sequence Analysis of 77.7 kb of the Human V[beta] T-Cell Receptor Gene Locus: Direct Primer-Walking Using Cosmid Template DNAs
(Elsevier, 1994-03-15)
The nucleotide sequence of 77.7 kb from the human T-cell receptor [beta]-chain locus was determined directly from three overlapping cosmid clones using the primer-walking approach. Computer-aided analyses of this sequence ...
Localization of the Gene for ATP Citrate Lyase (ACLY) Distal to Gastrin (GAS) and Proximal to D17S856 on Chromosome 17q12-q21
(Elsevier, 1994-05-15)
The gene encoding ATP-citrate lyase, designated ACLY, was mapped to human chromosome 17q12-q21 by PCR on a panel of human/rodent somatic cell hybrids and localized to 17q21.1 by PCH on a panel of radiation hybrids. The ...
Localization of the Gene for Pigment Epithelium-Derived Factor (PEDF) to Chromosome 17p13.1 and Expression in Cultured Human Retinoblastoma Cells
(Elsevier, 1994-01-15)
The gene for pigment epithelium-derived factor (PEDF) was localized to chromosome 17 by the analysis of three independent somatic cell hybrid panels. Fluorescence in situ hybridization shows a specific hybridization signal ...
Yeast expression vectors using RNA polymerase III promoters
(Elsevier, 1994-12-30)
A series of Saccharomyces cerevisiae -- Escherichia coli shuttle vectors is described in which small RNAs can be stably expressed in yeast from two different promoters for RNA polymerase III transcription. The vectors are ...
Chromosomal Localization of Four Human VH1-like Protein-Tyrosine Phosphatases
(Elsevier, 1994-07-15)
Four human protein-tyrosine phosphatase (PTPase) genes of the VH1-like subclass were cloned by low-stringency screening of a genomic library. These genes were localized to their respective chromosomes by G-banding and ...
Characterization of the Determinant (traB) Encoding Sex Pheromone Shutdown by the Hemolysin/Bacteriocin Plasmid pAD1 in Enterococcus faecalis
(Elsevier, 1994-03)
pAD1 is a hemolysin/bacteriocin plasmid originally identified in Enterococcus faecalis DS16. It encodes a mating response to a peptide sex pheromone, cAD1, secreted by recipient bacteria. Once pAD1 is acquired, production ...
Kidney and Retinal Defects (Krd), a Transgene-Induced Mutation with a Deletion of Mouse Chromosome 19 That Includes the Pax2 Locus
(Elsevier, 1994-09-15)
The semidominant mutation Krd (kidney and retinal defects) was identified in transgenic line Tg8052. Krd/+ mice have a high incidence of kidney defects including aplastic, hypoplastic, and cystic kidneys. Retinal defects ...
Conserved Linkage of Early Growth Response 4, Annexin 4, and Transforming Growth Factor [alpha] on Mouse Chromosome 6
(Elsevier, 1994-01-15)
The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor a (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on human chromosome 2p11-p13. ...
An Integrated Physical Map of 210 Markers Assigned to the Short Arm of Human Chromosome 11
(Elsevier, 1994-06)
Using a panel of patient cell lines with chromosomal breakpoints, we constructed a physical map for the short arm of human chromosome 11. We focused on 11p15, a chromosome band harboring at least 25 known genes and associated ...