Now showing items 1-9 of 9
Individual differences in sensitivity to nicotine: Implications for genetic research on nicotine dependence
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1995-03)
Recent evidence suggests that cigarette smoking has a heritability index around 53%. While related research on underlying mechanisms also supports the idea that genetic factors contribute to nicotine dependence—as well as ...
Embryonic regulation of histone ubiquitination the sea urchin
(Wiley Subscription Services, Inc., A Wiley Company, 1995)
We have used quantitative 2-D protein electrophoresis and immunoprecipitation to study the patterns of histone ubiquitination at 10 h and 36 h of embryonic development in Strongylocentrotus purpuratus. Variants csH2A, ΑH2A, ...
Psychiatric comorbidity of smoking and nicotine dependence
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1995-03)
Recent epidemiologic studies have revealed that comorbidity of psychiatric disorders is far more pervasive than previously suspected. Strong associations have been reported between specific substance use disorders and ...
Detection of genome similarity as an exploratory tool for mapping complex traits
(Wiley Subscription Services, Inc., A Wiley Company, 1995)
For one- and two-trait-locus models, we show that the lod score based on affected relative pairs or trios is a monotonically increasing function of the genome similarity measured by the proportion of alleles shared identical ...
Recombination fraction estimate of zero in the presence of apparent recombinants: Effects of incomplete penetrance and sporadic cases
(Wiley Subscription Services, Inc., A Wiley Company, 1995)
For a fully penetrant trait, apparent recombinants between the trait and marker loci result in an estimate of the recombination fraction θ > 0. Given allowance for reduced penetrance and/or sporadic cases, this no longer ...
Two highly polymorphic CA repeats in the Menkes gene (ATP7A)
(Springer-Verlag, 1995-09)
Two highly polymorphic CA repeats have been identified in the Menkes gene ( ATP7A ). These repeats should be useful for prenatal diagnosis and carrier detection in families with Menkes disease and X-linked cutis laxa. The ...
Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota
(Springer-Verlag, 1995-09)
A variant of the angiotensinogen gene, M235T, has been associated with essential hypertension in selected subjects from Paris, France and Salt Lake City, Utah. In the present report, we studied a population-based sample ...
An intragenic Taq I polymorphism in the faciogenital dysplasia (FGD1) locus, the gene responsible for Aarskog syndrome
(Springer-Verlag, 1995-10)
A Taq I polymorphism, located in intron 4 of the faciogenital dysplasia ( FGD1 ) gene, the gene responsible for Aarskog syndrome, is described. FGD1 encodes a putative Rho/Rac guanine nucleotide exchange factor involved ...
Dinucleotide polymorphism at the DXS1178 locus is tightly linked to PGK1 at Xq13
(Springer-Verlag, 1995-04)
A polymorphic CA repeat (locus name DXS1178 ) was isolated from a 1-megabase YAC (OTCC) containing the OTC gene, located at Xp21.1. However, amplification in human-rodent hybrid cells and segregation analysis in three CEPH ...