Now showing items 1-6 of 6
Glucocorticoid-reinforced responding in the rhesus monkey
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-11)
Rationale: Glucocorticoids have been reported to have rewarding effects in rats and may lead to drug-seeking behavior in humans under some circumstances. Objectives: The present study investigated whether glucocorticoids ...
Quadazocine decreases responding reinforced by ethanol, sucrose, and phencyclidine fluid deliveries in rhesus monkeys: comparison to naltrexone’s effects
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-06)
Rationale: The endogenous opioid system may mediate the reinforcing effects of ethanol as well as sweet-tasting solutions. For example, opioid antagonists, such as naltrexone, reduce ethanol- and sucrose-reinforced ...
Oral self-administration of ethanol, phencyclidine, methadone, pentobarbital and quinine in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-11)
Rationale: Simultaneous and sequential drug use among clinical populations is the norm, whereas the pattern of self-administration of multiple drugs among non-human primate populations has not been thoroughly explored. ...
Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-07)
Rationale and Objectives : The present study was designed to assess possible abuse-related effects of the endogenous neuroactive steroid pregnanolone (3α-hydroxy-5β-pregnan-20-one) and the orally bioavailable, water-soluble ...
Systemic effects of E-2078, a stabilized dynorphin A(1–8) analog, in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-04)
Rationale : E-2078 ([ N -methyl-Tyr 1 , N -methyl-Arg 7 , d -Leu 8 ] dynorphin A(1–8) ethylamide) is a dynorphin A(1–8) analog with a reduced tendency to be biotransformed, when compared to the unmodified opioid peptide. ...
Local administration of Δ9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-04)
Rationale: Cannabinoids can reduce nociceptive responses by acting on peripheral cannabinoid receptors in rodents. Objectives: The study was conducted to evaluate the hypothesis that local administration of Δ 9 ...