Now showing items 1-10 of 11
Pleiotropy Analysis of Quantitative Traits at Gene Level by Multivariate Functional Linear Models
(John Wiley & Sons, 2015-05)
In genetics, pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. A common approach is to analyze the phenotypic traits separately using univariate analyses and combine the test results ...
Identification of FAK substrate peptides via colorimetric screening of a one‐bead one‐peptide combinatorial library
(Wiley Periodicals, Inc., 2015-04)
Label‐free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity
(Wiley Periodicals, Inc., 2015-07)
Robust and Powerful Affected Sibpair Test for Rare Variant Association
(Wiley Periodicals, Inc., 2015-07)
Advances in DNA sequencing technology facilitate investigating the impact of rare variants on complex diseases. However, using a conventional case‐control design, large samples are needed to capture enough rare variants ...
Protein Structure and Function Prediction Using I‐TASSER
(Wiley Periodicals, Inc., 2015-12)
I‐TASSER is a hierarchical protocol for automated protein structure prediction and structure‐based function annotation. Starting from the amino acid sequence of target proteins, I‐TASSER first generates full‐length atomic ...
Proteomics analysis of rough endoplasmic reticulum in pancreatic beta cells
(Wiley Periodicals, Inc., 2015-05)
Evaluating the Calibration and Power of Three Gene‐Based Association Tests of Rare Variants for the X Chromosome
(Wiley Periodicals, Inc., 2015-11)
Although genome‐wide association studies (GWAS) have identified thousands of trait‐associated genetic variants, there are relatively few findings on the X chromosome. For analysis of low‐frequency variants (minor allele ...
Using PepExplorer to Filter and Organize De Novo Peptide Sequencing Results
(Wiley Periodicals, Inc.Humana Press, 2015-09)
PepExplorer aids in the biological interpretation of de novo sequencing results; this is accomplished by assembling a list of homolog proteins obtained by aligning results from widely adopted de novo sequencing tools against ...
Methods for Association Analysis and Meta‐Analysis of Rare Variants in Families
(Wiley Periodicals, Inc.Springer‐Verlag, 2015-05)
Advances in exome sequencing and the development of exome genotyping arrays are enabling explorations of association between rare coding variants and complex traits. To ensure power for these rare variant analyses, a variety ...
Architecture-Function Analysis of the Kinetochore Reveals the Mechanism of Spindle Assembly Checkpoint Signaling.
(2015)
In a dividing cell, equal segregation of chromosomes between the two daughters is necessary for accurate genome inheritance. For successful segregation, chromosomes must attach to and move along microtubule tracks provided ...