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A novel approach towards the synthesis of the 3,4,5-trihydro-1,3-diazepin-5-ol ring structure
(Elsevier, 1983)
A catalytic reduction of the nitrile portion of the trimethylsilyl cyanohydrin to a primary amine has produced an situ annulation to generate the 3,4,5-trihydro-1,3-diazepin-5-ol ring. This ring substructure has demonstrated ...