Now showing items 1-4 of 4
A Mystery of Muscle: Establishing Mechanisms of Toxicity in Polyglutamine Disease
(2022)
Polyglutamine disorders encompass nine uniformly fatal diseases for which there are no disease course altering therapies. This group of related diseases share a key source: expansion of a CAG microsatellite repeat in genes ...
Molecular Mechanisms of G?i Signaling Selectivity
(2023)
Nearly all of human physiology is under the control of G protein-coupled receptors (GPCRs), which transmit signals from extracellular stimuli to affect intracellular processes. The heterotrimeric G proteins that these ...
Inhibition of Nucleotide and One-Carbon Metabolism for the Treatment of Cancer
(2021)
Metabolic reprogramming in cancer was first described in the early to mid-1900s and later labeled as a hallmark. Rapidly proliferating cells require sufficient concentrations of nucleotides and other biomass precursor ...
Machine Learning Guided Drug Discovery: Comprehensive Application in Janus Kinase Inhibitor Design
(2023)
Conventional drug discovery is often plagued by resource-intensive processes, leading to significant attrition rates due to challenges such as efficacy shortcomings, safety concerns and suboptimal pharmacokinetics (PK). ...