Now showing items 1-7 of 7
Elucidating the Genetic Basis of Pigmentation Differences between Drosophila Species.
(2012)
Understanding how phenotypes change has been a long-standing question in evolutionary biology. The research presented here investigates the genetic basis of the pigmentation difference exhibited between the dark pigmented ...
Patched Together: cis-Regulatory Logic of the Hedgehog Response.
(2016)
Understanding the processes that control how we develop from a fertilized embryo to a functional adult is paramount for treating the diseases that result when these processes are disrupted at any stage of life. My dissertation ...
Inside or Out: Characterizing petrobactin use by Bacillus anthracis
(2018)
Bacillus anthracis is a Gram-positive, spore-forming bacillus and causes the disease anthrax. Anthrax is a deadly infection that begins with phagocytosis of a B. anthracis spore by an antigen presenting cell and ends when ...
The Evolution of Gene Regulation in Drosophila.
(2014)
Differences in gene expression drive phenotypic diversity. At the level of transcription, these differences are largely controlled by the complex interplay between trans-acting factors and the cis-regulatory sequences to ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
The Application of Genetic, In Silico and In Vitro Tools to Elucidate the Biology of a Functional Amyloid Fiber.
(2010)
Curli are thin aggregative fimbriae produced by many Enterobacteriaceae as a structural component of biofilms. Curli share many biochemical and biophysical properties with amyloid fibers which are often associated with ...
Directed Evolution Designed to Optimize the in vivo Protein Folding Environment.
(2010)
Protein folding is assisted by molecular chaperones and folding catalysts in vivo. Understanding how chaperones are regulated and how they function in vivo may provide new avenues for developing protein folding modulators. ...