Now showing items 1-6 of 6
A Mystery of Muscle: Establishing Mechanisms of Toxicity in Polyglutamine Disease
(2022)
Polyglutamine disorders encompass nine uniformly fatal diseases for which there are no disease course altering therapies. This group of related diseases share a key source: expansion of a CAG microsatellite repeat in genes ...
CRISPR/Cas9 Inducible Gene Knockout in Brown Adipose Tissue
(2021)
The ability to study adipose tissue in vivo has centered around the use of transgenic mice, which require significant time, resources, and investment to generate. With nearly 40% of adults in the United States considered ...
Sex-Specific Roles for Melanin-Concentrating Hormone Neurons Linking the Neuroendocrine Reproductive Axis and Sleep
(2023)
My dissertation research has centered around three aspects of reproductive physiology and the role of MCH neurons therein: lactation, the regulation of pubertal timing and fertility, and the effect of gonadal steroids on ...
Epigenetic Reprogramming of Sweet Taste by Diet
(2021)
Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here, we show that in ...
Roles for GLI Transcription Factors in Pancreas Development and Disease
(2022)
The Hedgehog (HH) signaling pathway plays a fundamental role in patterning numerous developing tissues, and dysregulated HH signaling has been linked to malignant human diseases. HH signaling is regulated on a transcriptional ...
There and Back Again: Regulation of Stem Cell Homeostasis and Dedifferentiation in the Drosophila Male Germline by me31b
(2021)
Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. However, even stem cells can be damaged or lost, leading to a tissue that ...