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Synthetic Strategies and Parameters Involved in the Synthesis of Oligodeoxyribonucleotides According to the Phosphoramidite Method
(Wiley Periodicals, Inc.Plenum, 2000-02)
The phosphoramidite approach has had a major impact on the synthesis of oligonucleotides. This unit describes parameters that affect the performance of this method for preparing oligodeoxyribonucleotides, as well as a ...
High levels of non-activated receptors in glucocorticoid-sensitive S49wt mouse lymphoma cells incubated with dexamethasone
(Elsevier, 1994-10)
Upon agonist binding the heteromeric glucocorticoid receptor complex under goes a conformational change (receptor activation). This event involves the dissociation of a dimer of 90 kDa heat shock proteins. Whereas receptor ...
Relationship between the subunit structure of insulin receptor and its competence to bind insulin and undergo phosphorylation
(Elsevier, 1984-11-01)
Insulin receptor partially purified from human placenta by chromatography on immobilized wheat germ agglutinin was subjected to affinity cross linking to determine the relationship between the subunit structure of the ...
Leukotriene C4 induces vasogenic cerebral edema in rats
(Elsevier, 1984-06)
Leukotriene C4 (LTC4) is reported to neither contract nor relax isolated human cerebra artdial strips (1), but in skin LTC4 will increase vascular permeability in post capillary venules, increase blood flow (2) and elicit ...
Chemical Reagents for Investigating the Major Groove of DNA
(Wiley Periodicals, Inc.Oxford University Press, 2001-07)
Chemical modification provides an inexpensive and rapid method for characterizing the structure of DNA and its association with drugs and proteins. Numerous conformation‐specific probes are available, but most investigations ...
Characterization of gastrin amidation in the rat and porcine antrum: comparison with the pituitary
(Elsevier, 1990-04-24)
The formation of biologically active gastrin from glycine-extended processing intermediates occurs via the action of a peptide [alpha]-amidating enzyme. The observation that gastrin exists primarily as unamidated precursors ...
Synthesis of N2‐Substituted Deoxyguanosine Nucleosides from 2‐Fluoro‐6‐O‐(Trimethylsilylethyl)‐2′‐Deoxyinosine
(Wiley Periodicals, Inc.Aldrich Chemical Co., 2000-02)
Syntheses of N2‐substituted nucleosides have been studied for many years, primarily with ribonucleosides. However, the primary route to these compounds requires acidic conditions that are too vigorous for the acid‐labile ...