Now showing items 1-10 of 10
Using sex-averaged genetic maps in multipoint linkage analysis when identity-by-descent status is incompletely known
(Wiley Subscription Services, Inc., A Wiley Company, 2006-07)
The ratio of male and female genetic map distances varies dramatically across the human genome. Despite these sex differences in genetic map distances, most multipoint linkage analyses use sex-averaged genetic maps. We ...
Estimating the power of variance component linkage analysis in large pedigrees
(Wiley Subscription Services, Inc., A Wiley Company, 2006-09)
Variance component linkage analysis is commonly used to map quantitative trait loci (QTLs) in general pedigrees. Large pedigrees are especially attractive for these studies because they provide greater power per genotyped ...
Optimal designs for two-stage genome-wide association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2007-11)
Genome-wide association (GWA) studies require genotyping hundreds of thousands of markers on thousands of subjects, and are expensive at current genotyping costs. To conserve resources, many GWA studies are adopting a ...
Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2009-09)
Genome-wide association studies are helping to dissect the etiology of complex diseases. Although case-control association tests are generally more powerful than family-based association tests, population stratification ...
An evaluation of the replicate pool method: quick estimation of genome-wide linkage peak p -values
(Wiley Subscription Services, Inc., A Wiley Company, 2006-05)
The calculation of empirical p -values for genome-wide non-parametric linkage tests continues to present significant computational challenges for many complex disease mapping studies. The gold standard approach is to use ...
A comparison of approaches to account for uncertainty in analysis of imputed genotypes
(Wiley Subscription Services, Inc., A Wiley Company, 2011-02)
The availability of extensively genotyped reference samples, such as “The HapMap” and 1,000 Genomes Project reference panels, together with advances in statistical methodology, have allowed for the imputation of genotypes ...
Methods for Association Analysis and Meta‐Analysis of Rare Variants in Families
(Wiley Periodicals, Inc.Springer‐Verlag, 2015-05)
Advances in exome sequencing and the development of exome genotyping arrays are enabling explorations of association between rare coding variants and complex traits. To ensure power for these rare variant analyses, a variety ...
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
(Wiley Subscription Services, Inc., A Wiley Company, 2010-12)
Genome-wide association studies (GWAS) can identify common alleles that contribute to complex disease susceptibility. Despite the large number of SNPs assessed in each study, the effects of most common SNPs must be evaluated ...
Relative impact of indels versus SNPs on complex disease
(Wiley Periodicals, Inc., 2019-02)
It is unclear whether insertions and deletions (indels) are more likely to influence complex traits than abundant single‐nucleotide polymorphisms (SNPs). We sought to understand which category of variation is more likely ...
Estimation of DNA contamination and its sources in genotyped samples
(Wiley Periodicals, Inc., 2019-12)
Array genotyping is a cost‐effective and widely used tool that enables assessment of up to millions of genetic markers in hundreds of thousands of individuals. Genotyping array data are typically highly accurate but sensitive ...