Now showing items 1-10 of 61
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
Imaging Changes after Stereotactic Radiosurgery of Primary and Secondary Malignant Brain Tumors
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-01)
After radiosurgery of malignant tumors, it can be difficult to discriminate between transient treatment effects, radiation necrosis, and tumor progression on post-treatment imaging. Misinterpretation of an enlarging lesion ...
Expedition Inspiration Fund for Breast Cancer Research Meeting 2003
(Kluwer Academic Publishers; Springer Science+Business Media, 2003-07)
Identifying and Validating Causal Genetic Alterations in Human Breast Cancer
(Kluwer Academic Publishers; Springer Science+Business Media, 2003-04)
An important mechanism for the activation of proto-oncogenes in human breast and other cancers is gene amplification, which results in gene overexpression at both the message and the protein levels. Recent studies have ...
Multiple Signaling Pathways are Activated During Insulin-like Growth Factor-I (IGF-I) Stimulated Breast Cancer Cell Migration
(Kluwer Academic Publishers; Springer, 2005-09)
In order to display the full metastatic phenotype, the cancer cell must acquire the ability to migrate. In breast cancer, we have previously shown that insulin-like growth factor I (IGF-I) enhances cell motility in the ...
Breast Cancer Research and Treatment
(Kluwer Academic Publishers; Springer Science+Business Media, 2001-09)
Glycine Protection of PC-12 Cells Against Injury by ATP-Depletion
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-06)
A distinctive mechanism of cell injury during ATP depletion involves the loss of cellular glycine. The current study examined whether provision of glycine during ATP depletion can prevent injury in PC-12 cells, a cell line ...
Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor – a pharmacokinetic study
(Kluwer Academic Publishers; Springer, 2005-07)
Solvent facilitated perfusion (SFP) has been proposed as a technique to increase the delivery of chemotherapeutic agents to tumors. SFP entails direct injection of the agent into the tumor in a water-miscible organic ...
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
(Kluwer Academic Publishers; Springer, 2005-06)
Tamoxifen has been a mainstay of adjuvant therapy for breast cancer for many years. We sought to determine if genetic variability in the tamoxifen metabolic pathway influenced overall survival in breast cancer patients ...
Intramedullary Spinal Tumors of Disordered Embryogenesis
(Kluwer Academic Publishers; Springer Science+Business Media, 2000-05)
Abnormal spinal embryogenesis is quite commonplace. While greater than 90 percent of these errors of embryogenesis leads to occult spinal dysraphism with minimal neurologic or orthopedic sequelae, there is a significant ...