Now showing items 1-6 of 6
Characterizing and Targeting the Chromatin Determinants of Cancer Cell Identity: Cancer's Addiction to its Originating Cellular Lineage
(2021)
Cancer is a complex disease that is initiated by genetic perturbations in normal cells leading to uncontrollable cellular division. The ensuing tumor mass, at both primary and distant metastatic sites, hinders the normal ...
Development and Application of Methods to Discover Cancer-Associated Transcript Variants.
(2016)
Cancer is and has long been a major threat to human health, and in seeking to better treat cancer, we seek first to better understand cancer. Consequently, the current era of cancer research has aimed to catalog the full ...
Identifying, Modeling and Targeting IGF-II Overexpression in the Adrenocortical Carcinoma.
(2012)
Insulin-like growth factor-II (IGF-II) is a mitogenic growth factor that elicits cellular effects primarily through its downstream signaling pathway. The IGF signaling pathway is a critical cellular system for stimulating ...
Roles for GLI Transcription Factors in Pancreas Development and Disease
(2022)
The Hedgehog (HH) signaling pathway plays a fundamental role in patterning numerous developing tissues, and dysregulated HH signaling has been linked to malignant human diseases. HH signaling is regulated on a transcriptional ...
Investigating the Role of AGO2-RAS Interaction in Mutant RAS Driven Cancers
(2022)
The RAS genes are among the most commonly mutated genes in cancer. These genes code for GTPases that act as growth factor receptor-regulated molecular switches. Mutations in RAS lead to a loss in GTP hydrolysis and cause ...
The Role of Long Noncoding RNA SChLAP1 in Prostate Cancer
(2017)
Prostate cancer is the most common malignancy in U.S. men, accounting for nearly 30,000 deaths annually. While the majority of prostate cancers are indolent, a subset of patients has aggressive disease. However, the molecular ...