Now showing items 1-10 of 10
A NMR Investigation of Structure and Allostery in the Hsp70 Chaperone System.
(2010)
The Hsp70 Chaperone system is a complex molecular machine composed of proteins. It is responsible for assisting in protein folding/refolding/processing and transport. Hsp70 proteins have been historically associated with ...
Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.
(2010)
Wnt signaling plays a critical role in numerous cellular processes including embryonic development, cell proliferation and tissue homeostasis. The multifunctional protein β-catenin is the primary mediator of canonical Wnt ...
(1) The Relationship of Protein Expression and Cell Division, (2) 3D Imaging of Cells Using Digital Holography, and (3) General Chemistry Enrollment at University of Michigan.
(2012)
Chapter 1: We evaluated the relationship between cell division and protein expression when using commercial poly(ethylenimine) (PEI)-based polyplexes. The membrane dye PKH26 was used to assess cell division, and cyan ...
Chemical Modulators of Heat Shock Protein 70 (Hsp70) Validate this Molecular Chaperone as a Target for Tauopathy
(2016)
Misregulation of tau, an intrinsically disordered protein, is implicated in Alzheimer’s disease (AD) and more than 15 related tauopathies. These diseases are characterized by the accumulation of tau aggregates into insoluble ...
Development of a Chemoproteomic Approach to Study Kinase-Substrate Interactions and the Discovery of CDK4 as a 4E-BP1 Kinase
(2019)
An instrumental aspect of cancer progression is the acquired deregulation of the cellular processes that regulate growth and proliferation. Most of these processes are, at some level, controlled by a kinase-catalyzed change ...
Inhibition of Nucleotide and One-Carbon Metabolism for the Treatment of Cancer
(2021)
Metabolic reprogramming in cancer was first described in the early to mid-1900s and later labeled as a hallmark. Rapidly proliferating cells require sufficient concentrations of nucleotides and other biomass precursor ...
Understanding Pre-mRNA Dynamics in Single Spliceosome Complexes.
(2013)
The spliceosome is a large RNA-protein complex that catalyzes pre-mRNA splicing by removing sequences called introns and joining of the remaining sequences, called exons, to produce a mature mRNA. Despite over a quarter ...
Specialized Metabolites and Related Biosynthetic Enzymes in Tomato Glandular Trichomes: Defining Biological Functions of Specific Gland Types.
(2011)
Trichomes are tiny appendages that grow out from the surfaces of leaves, stems, flowers, and other above-ground parts of many plants. They contribute to important biological functions such as determent of herbivores, ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...