Now showing items 1-10 of 100
β-funaltrexamine antagonizes the discriminative stimulus effects of morphine but not naltrexone in pigeons
(Springer-Verlag, 1987-02)
Antagonistic actions of the irreversible, μ-selective antagonist β-funaltrexamine (β-FNA) were evaluated in pigeons trained to discriminate among intramuscular injections of morphine (5.6 mg/kg), saline, and naltrexone ...
The effects of footshock stress on regional brain dopamine metabolism and pituitary [beta]-endorphin release in rats previously sensitized to amphetamine
(Elsevier, 1987-07)
The repeated intermittent administration of amphetamine (AMP) produces an enduring enhancement in the response of dopamine (DA) systems in the brain to a subsequent "challenge" with amphetamine. However, former amphetamine ...
Development of hypothalamic opioid neurons: A combined immunocytochemical and [3H]thymidine autoradiographic study
(Elsevier, 1985-02)
Using a combined technique of immunocytochemistry and [3H]thymidine autoradiography, we have determined the "birth-date" of opioid peptide containing neurons in three hypothalamic nuclei. These include proopiomelanocortin ...
Antagonism of the discriminative effects of ethylketazocine, cyclazocine, and nalorphine in macaques
(Springer-Verlag, 1984-09)
dl -Ethylketazocine (EKC, 0.01 mg/kg) and saline were established as discriminative stimuli for food-maintained responding in macaque monkeys. Thirty consecutive presses on a right or left lever were reinforced with food, ...
Enkephalinase: Selective inhibitors and partial characterization
(Elsevier, 1980)
There are at least two types of enzymes in brain, endopeptidases and aminopeptidases, which metabolize enkephalins. Evidence is presented to suggest that enkephalinase, an endopeptidase cleaving at the Gly-Phe bond, is ...
A sensitive coupled HPLC/RIA technique for separation of endorphins: Multiple forms of B-endorphin in rat pituitary intermediate vs. anterior lobe
(Elsevier, 1981-08)
A technique is described which couples High Performance Liquid Chromatography (HPLC) to radioimmuno assays (RIA), thus achieving high sensitivity with good specificity. This method allows the separation and detection of ...
Escape from dexamethasone suppression: Possible role of an impaired inhibitory opioid mechanism
(Elsevier, 1983)
1. 1. Several lines of evidence indicate that the activity of the hypothalamus-pituitary-adrenal (HPA) axis in depression is disinhibited.2. 2. Escape from dexamethasone suppression, although not limited to is more frequent ...
Electroencephalographic assessment of the role of [delta] receptors in opioid peptide - induced seizures
(Elsevier, 1984-12)
DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for [delta] opioid receptors. Intracerebroventricular (i.c.v.) ...
Strategies for studying opioid peptide regulation at the gene, message and protein levels
(Elsevier, 1984)
Three opioid peptide precursors have been isolated and characterized in endocrine and nervous tissue: pro-opiomelanocortin, pro-enkephalin, and pro-dynorphin. Since each of those opioid peptide systems have been extensively ...
Contribution of social factors to opiate-induced activation in the mouse
(Elsevier, 1981-04)
Adult male Swiss-Webster mice of varying group size (single, or in groups of 2, 3, or 4) were injected with vehicle, or 25 or 50 mg/kg of morphine sulfate. In comparison with vehicle, morphine-injected mice showed heightened ...