Now showing items 1-10 of 62
β-funaltrexamine antagonizes the discriminative stimulus effects of morphine but not naltrexone in pigeons
(Springer-Verlag, 1987-02)
Antagonistic actions of the irreversible, μ-selective antagonist β-funaltrexamine (β-FNA) were evaluated in pigeons trained to discriminate among intramuscular injections of morphine (5.6 mg/kg), saline, and naltrexone ...
The effects of footshock stress on regional brain dopamine metabolism and pituitary [beta]-endorphin release in rats previously sensitized to amphetamine
(Elsevier, 1987-07)
The repeated intermittent administration of amphetamine (AMP) produces an enduring enhancement in the response of dopamine (DA) systems in the brain to a subsequent "challenge" with amphetamine. However, former amphetamine ...
Antagonism of the discriminative effects of ethylketazocine, cyclazocine, and nalorphine in macaques
(Springer-Verlag, 1984-09)
dl -Ethylketazocine (EKC, 0.01 mg/kg) and saline were established as discriminative stimuli for food-maintained responding in macaque monkeys. Thirty consecutive presses on a right or left lever were reinforced with food, ...
Escape from dexamethasone suppression: Possible role of an impaired inhibitory opioid mechanism
(Elsevier, 1983)
1. 1. Several lines of evidence indicate that the activity of the hypothalamus-pituitary-adrenal (HPA) axis in depression is disinhibited.2. 2. Escape from dexamethasone suppression, although not limited to is more frequent ...
Contribution of social factors to opiate-induced activation in the mouse
(Elsevier, 1981-04)
Adult male Swiss-Webster mice of varying group size (single, or in groups of 2, 3, or 4) were injected with vehicle, or 25 or 50 mg/kg of morphine sulfate. In comparison with vehicle, morphine-injected mice showed heightened ...
Discriminative stimulus effects of pentobarbital in rhesus monkeys: Tests of stimulus generalization and duration of action
(Springer-Verlag, 1982-02)
Rhesus monkeys were trained to emit 20 or 30 consecutive responses on one lever following an IM injection of pentobarbital (10 or 18 mg/kg) and the same number of consecutive responses on another lever following an injection ...
Comparison of opioid agonists in maintaining responding and in suppressing morphine withdrawal in rhesus monkeys
(Springer-Verlag, 1981-09)
Sixteen opioid agonists were studied for their capacity both to maintain responding previously reinforced by codeine and to suppress the withdrawal syndrome induced by morphine deprivation in rhesus monkeys. All compounds, ...
Some thoughts on the relations between animal and human drug-taking
(Elsevier, 1983)
1. 1. Results of studies of drug self-administration have frequently been suggested as indicators of the potential for abuse of these drugs by humans. Historical data (pre 1970), although scant, supported this suggestion ...
A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats
(Springer-Verlag, 1987-09)
Directly observable behavioral effects of the N-methyl- D -aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovalerate (AP5) (10–1,000 mg/kg IP, 0.18–5.6 μmol/rat ICV) and of phencyclidine (PCP) (3.2–56 mg/kg IP, ...
Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons
(Springer-Verlag, 1985-03)
Six pigeons, trained to peck a response key on a fixed-ratio 20 schedule of food reinforcement, were used to examine the effects of morphine, naltrexone, and dextrorphan, before, during, and after chronic treatment with ...