Now showing items 1-10 of 44
Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-01)
Ketamine is an N -methyl- D -aspartate (NMDA) receptor antagonist with psychotogenic and dissociative effects in healthy humans. These cognitive and perceptual effects in humans are reportedly reduced by benzodiazepine ...
Selective inhibition by alcohol and cortisol of natural killer cell activity of lymphocytes from cord blood
(Elsevier, 1994-12)
1. 1. The immunosuppressive effects of drugs such as alcohol or hormones such as cortisol may be age-related. To test this hypothesis, the authors investigated the in vitro effects of ethanol (EtOH) and cortisol on Natural ...
Effects of tobacco smoking on the topographic EEG I
(Elsevier, 1994-09)
1. 1. The EEG and cardiovascular effects of smoking tobacco cigarettes of varying nicotine content were studied in Japanese chronic tobacco smokers.2. 2. Thirteen female and fifteen male adult normal volunteers were recruited ...
Dexamethasone attenuation of the cortisol response to nicotine in smokers
(Springer-Verlag, 1990-06)
The effect of corticosteroids upon the cortisol response to nicotine from smoking was investigated in five heavy smokers. Corticosteroid activity was manipulated by administering dexamethasone, a synthetic glucocortoicoid ...
Effects of neuropeptide Y, insulin, 2-deoxyglucose, and food deprivation on food-motivated behavior
(Springer-Verlag, 1995-08)
The current study demonstrates the ability of neuropeptide Y (NPY) to increase break points under a progressive ratio 1 (PR1) reinforcement schedule. An initial response resulted in delivery of a food reinforcer (45 mg ...
Glucocorticoid-reinforced responding in the rhesus monkey
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-11)
Rationale: Glucocorticoids have been reported to have rewarding effects in rats and may lead to drug-seeking behavior in humans under some circumstances. Objectives: The present study investigated whether glucocorticoids ...
Competitive and uncompetitive N -methyl- d -aspartate antagonist discriminations in pigeons: CGS 19755 and phencyclidine
(Springer-Verlag, 1995-03)
The purpose of the present studies was to examine representative uncompetitive and competitive NMDA antagonists, as well as the glycine/NMDA antagonist, HA 966, in pigeons trained to discriminate either PCP or CGS 19755 ...
Ethanol effects on self-administration of alfentanil, cocaine, and nomifensine in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1997-04)
A common form of polydrug use is that of cocaine and ethanol. The identification of an ethanol-cocaine combination product, cocaethylene, with properties in common with cocaine, has led to speculation that this metabolite ...
Discriminative stimulus effects of a centrally administered, delta-opioid peptide ( d -Pen 2 - d -Pen 5 -enkephalin) in pigeons
(Springer-Verlag, 1996-10)
The present study assessed the discriminative stimulus effects of the delta-opioid agonist [ d -Pen 2 - d -Pen 5 ]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between ICV injections ...
Differential effects of systemically administered nor-binaltorphimine (nor-BNI) on κ-opioid agonists in the mouse writhing assay
(Springer-Verlag, 1994-07)
The opioid antagonist effects of systemically administered nor-binaltorphimine (nor-BNI) were evaluated against the kappa agonists CI-977, U69,593, U50,488, ethylketocyclazocine (EKC), Mr2034 and bremazocine, the mu agonist ...