Now showing items 1-10 of 2826
The presence of two [alpha]-MSH positive cell groups in rat hypothalamus
(Elsevier, 1979-09-01)
Oral Absorption of Peptides: The Effect of Absorption Site and Enzyme Inhibition on the Systemic Availability of Metkephamid
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-04)
In this study the intestinal degradation and absorption of a synthetic pentapeptide, metkephamid, were investigated in the rat by determination of its wall permeabilities in the small and large intestine and the extent and ...
Evaluation of Immunomodulatory Biomarkers in a Pressure Overload Model of Heart Failure
(Blackwell Publishing LtdWiley Periodicals, Inc., 2007-04)
Some side effects of heparin, heparinoids, and their antagonists
(Wiley Periodicals, Inc., 1966-05)
Letter to the Editor
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1999-02)
Stereoselective Systemic Disposition of Ibuprofen Enantiomers in the Dog
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1991-09)
The pharmacokinetics of ibuprofen are complicated by the unidirectional metabolic inversion of the (–)-R- to ( + )-S-enantiomer. Chiral inversion is of therapeutic significance since the drug’s pharmacologic activity has ...
Hepatic microsomal epoxidation of bromobenzene to phenols and its toxicological implication
(Elsevier, 1979-09-15)
In vitro microsomal hepatic epoxidation of bromobenzene in rats and mice is presented in this study. Formation of o-bromophenol via bromobenzene-2,3-epoxide and p-bromophenol via bromobenzene-3,4-epoxide was assayed ...
Whole‐cell biocatalysis platform for gram‐scale oxidative dearomatization of phenols
(Wiley Periodicals, Inc., 2019-06)
Technologies enabling new enzyme discovery and efficient protein engineering have spurred intense interest in the development of biocatalytic reactions. In recent years, whole‐cell biocatalysis has received attention as a ...
Novel method of estimating volume of distribution of a drug obeying Michaelis-Menten elimination kinetics
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1978-06)
The novel method of estimating the volume of distribution involves (a) administering an appropriate bolus intravenous dose of the drug, (b) starting a constant-rate intravenous infusion of the drug at the same time, (c) ...
Clinical and Economic Effectiveness of an Inpatient Anticoagulation Service
(Blackwell Publishing LtdWiley Periodicals, Inc., 1999-09)