Now showing items 1-5 of 5
Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling
(Wiley Periodicals, Inc.Humana, 2020-09)
Several metabolites serve as substrates for histone modifications and communicate changes in the metabolic environment to the epigenome. Technologies such as metabolomics and proteomics have allowed us to reconstruct the ...
Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo
(Wiley Periodicals, Inc., 2020-01)
Metastases are preceded by stochastic formation of a hospitable microenvironment known as the premetastatic niche, which has been difficult to study. Herein, we employ implantable polycaprolactone scaffolds as an engineered ...
Understanding Human Lung Development through In Vitro Model Systems
(Wiley Periodicals, Inc., 2020-06)
An abundance of information about lung development in animal models exists; however, comparatively little is known about lung development in humans. Recent advances using primary human lung tissue combined with the use of ...
The Anti‐G0 Manifesto: Should a problematic construct (G0) with no biological reality be removed from the cell cycle? Yes!
(Wiley Periodicals, Inc., 2021-03)
It is widely accepted that there exists a “resting” or “quiescent” state where a growing cell leaves the cell cycle to enter what is often called the “G0‐phase.” I propose that there is no biological reality to the “G0‐phase.” ...
Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies
(Wiley Periodicals, Inc., 2021-01)
An emerging concept is that quiescent mature skeletal cells provide an important cellular source for bone regeneration. It has long been considered that a small number of resident skeletal stem cells are solely responsible ...