Now showing items 1-10 of 85
Simultaneous Multislice Functional Magnetic Resonance Imaging.
(2016)
Functional magnetic resonance imaging (fMRI) is a valuable tool for mapping brain activity in many fields. Since functional activity is determined by temporal signal changes, undesired fluctuations from physiological motion ...
Evaluation of amonafide in disseminated malignant melanoma
(Kluwer Academic Publishers; Springer Science+Business Media, 1993-06)
Amonafide (AMF), NSC 308847 is an investigational anticancer drug acting as a DNA intercalating agent. This paper presents results of a phase II clinical study of AMF in disseminated malignant melanoma. Twenty patients, ...
Effects of metallic ions and diphosphonates on inhibition of pericardial bioprosthetic tissue calcification and associated alkaline phosphatase activity
(Elsevier, 1993-04)
This study focused on the association of extrinsic alkaline phosphatase (AP) activity with both early and advanced calcification of glutaraldehyde-pretreated bovine pericardial bioprosthetic (GPBP) tissue, and the inhibition ...
Representation of Somatosensory Evoked Potentials Using Discrete Wavelet Transform
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-04)
Objective. Somatosensory evoked potentials (SEP) have been shown to be a useful tool in monitoring of the central nervous system (CNS) during anaesthesia. SEP analysis is usually performed by an experienced human operator. ...
Continuous monitoring of analyte concentrations
(Elsevier, 1992)
We have investigated the application of a modified, heterogeneous, competitive enzyme immunoassay for the continuous measurement of small analytes in a medium stream. The analytical system contains two antibodies that are ...
Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-09)
Purpose : We have reported previously that the expression of E. coli dUTPase (dutE) can protect HT29 cells from 5-fluorodeoxyuridine (FdUrd)-induced DNA fragmentation and cytotoxicity. In the study reported here, we further ...
Carboplatin (CBDCA), iproplatin (CHIP), and high dose cisplatin in hypertonic saline evaluated for tubular nephrotoxicity
(Springer-Verlag, 1987-02)
We compared the acute tubular nephrotoxicity of three platinum compounds in children and adults with solid tumors by monitoring the urinary excretion of alanine aminopeptidase, N -acetyl-β-D-glucosaminidase, and total ...
An in vivo and in vitro trial of aclarubicin in metastatic breast cancer: a novel approach to the study of analogs
(Springer-Verlag, 1993-11)
Aclarubicin is an anthracycline antibiotic that differs from doxorubicin in its structure, mechanism of action, and preclinical toxicity profile, especially its reduced cardiotoxicity. We therefore conducted a side-by-side ...
Augmentation of hepatic doxorubicin extraction with extracorporeal filtration avoids the dose-dependent, nonlinear increase in AUC observed with systemic administration
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1997-12)
Purpose : Regional therapy of primary or metastatic liver cancer with low hepatic extraction ratio drugs such as doxorubicin is constrained by development of systemic toxicity. To examine the effect of augmentation of ...
Phase II trial of N-methylformamide in advanced head and neck cancer
(Kluwer Academic Publishers; Martinus Nijhoff Publishers ; Springer Science+Business Media, 1987-06)
Eighteen patients with advanced epidermoid carcinoma of the head and neck were entered into a phase II trial of N-Methylformamide (NMF), 800 mg/M 2 IV daily for 5 days every 4 weeks. Seventeen patients had received prior ...