Now showing items 1-6 of 6
Low-Flow Push-Pull Perfusion for Measuring Neurotransmitters with High Spatial and Temporal Resolution within the Living Brain.
(2013)
Low-flow push-pull perfusion is a technique for measuring neurotransmitters within the brain with ~200 μm resolution. Activity of neurotransmitters can vary on this size scale; therefore, low-flow push-pull may offer new ...
Advances in in Vivo Neurochemical Monitoring Using Microdialysis with Liquid Chromatography-Mass Spectrometry
(2020)
Improving our understanding of the central nervous system necessitates developing techniques capable of making neurochemical measurements in the complex extracellular environment of the brain within living animal models. ...
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.
(2014)
Alzheimer’s disease (AD) places a significant and dramatically increasing burden on society. While pathological hallmarks of this neurodegenerative disorder are known, the exact cause remains unclear. Acetylcholinesterase ...
Mass Spectrometry Based Techniques for In Vivo Neurochemical Monitoring.
(2012)
Neurotransmitter concentration in vivo reflects various behavioral and pharmacological events. Therefore, the measurement of neurochemical dynamics in live behaving animals’ brain is of crucial importance for the fundamental ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Fast Capillary Electrophoresis for the Study of Dopamine in the Central Nervous System.
(2011)
The study of neurochemical events in the central nervous system (CNS) with temporal resolution ranging from seconds to minutes facilitates the evaluation of intercellular communication on times scales that are relevant to ...