Now showing items 1-10 of 59
Modeling intra-tumor protein expression heterogeneity in tissue microarray experiments
(John Wiley & Sons, Ltd., 2008-05-20)
Tissue microarrays (TMAs) measure tumor-specific protein expression via high-density immunohistochemical staining assays. They provide a proteomic platform for validating cancer biomarkers emerging from large-scale DNA ...
A false-discovery-rate-based loss framework for selection of interactions
(John Wiley & Sons, Ltd., 2008-05-20)
Interaction effects have been consistently found important in explaining the variation in outcomes in many scientific research fields. Yet, in practice, variable selection including interactions is complicated due to the ...
Non-parametric estimation of gap time survival functions for ordered multivariate failure time data
(John Wiley & Sons, Ltd., 2004-06-30)
Times between sequentially ordered events (gap times) are often of interest in biomedical studies. For example, in a cancer study, the gap times from incidence-to-remission and remission-to-recurrence may be examined. Such ...
A shared random effects model for censored medical costs and mortality
(John Wiley & Sons, Ltd., 2006)
In this paper, we propose a model for medical costs recorded at regular time intervals, e.g. every month, as repeated measures in the presence of a terminating event, such as death. Prior models have related monthly medical ...
Semiparametric inferences for association with semi-competing risks data
(John Wiley & Sons, Ltd., 2005)
In many biomedical studies, it is of interest to assess dependence between bivariate failure time data. We focus here on a special type of such data, referred to as semi-competing risks data. In this article, we develop ...
Analysis on binary responses with ordered covariates and missing data
(John Wiley & Sons, Ltd., 2007-08-15)
We consider the situation of two ordered categorical variables and a binary outcome variable, where one or both of the categorical variables may have missing values. The goal is to estimate the probability of response of ...
Comparing the small sample performance of several variance estimators under competing risks
(John Wiley & Sons, Ltd., 2007-02-28)
We examine several variance estimators for cumulative incidence estimators that have been proposed over time, some of which are derived from asymptotic martingale or counting process theory, and some of which are developed ...
Estimation for paired binomial data with application to radiation therapy
(John Wiley & Sons, Ltd., 2001-11-30)
We compare and contrast several different methods for estimating the effect of treatment when responses are paired binomial observations. The ratio of binomial probabilities is the parameter of interest, while the binomial ...
Training of the next generation of biostatisticians: a call to action in the U.S.
(John Wiley & Sons, Ltd., 2006-10-30)
Two workshops (2001, 2003) were held by the National Institutes of Health (NIH) to examine the need to train more biostatisticians in the U.S. to meet the increasing opportunities in the biomedical research enterprise. The ...
Developing multicomponent interventions using fractional factorial designs
(John Wiley & Sons, Ltd., 2009-09-20)
Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and ...