Now showing items 1-7 of 7
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...
Membrane Curvature During Cell Migration
(2020)
Biological membranes serve as a physical barrier of cell and organelles. In addition, as biological membranes house numerous proteins, they also act as signaling hubs involved in the regulation of a wide array of cellular ...
Multidisciplinary Study of Soft Shape Morphing Systems
(2021)
Nature abounds with examples of shape morphing systems where an entity either gradually grows into a complex 3-D shape pattern or rapidly morphs into a new configuration. Inspired by the shape shifting capabilities of ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Solid State NMR Investigations of Lipid Bilayers and Biomembrane Binding Molecules: Dendrimers and Amylin.
(2010)
The goal of this project was to investigate the interaction between lipid binding molecules, such as peptides and drug compounds, with biological lipid bilayers. The results demonstrate that human amylin, a peptide hormone ...
Regulating Gene Expression Through DNA Mechanics: Tightly Looped DNA Represses Transcription.
(2010)
It is now widely accepted that the mechanical state of DNA can play a major role in regulating the activity of RNA polymerase (RNAP). Not only have the global levels of supercoiling been shown to regulate transcription, ...