Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity
dc.contributor.author | Hertz, Daniel L. | |
dc.contributor.author | Deal, Allison | |
dc.contributor.author | Ibrahim, Joseph G. | |
dc.contributor.author | Walko, Christine M. | |
dc.contributor.author | Weck, Karen E. | |
dc.contributor.author | Anderson, Steven | |
dc.contributor.author | Magrinat, Gustav | |
dc.contributor.author | Olajide, Oludamilola | |
dc.contributor.author | Moore, Susan | |
dc.contributor.author | Raab, Rachel | |
dc.contributor.author | Carrizosa, Daniel R. | |
dc.contributor.author | Corso, Steven | |
dc.contributor.author | Schwartz, Garry | |
dc.contributor.author | Graham, Mark | |
dc.contributor.author | Peppercorn, Jeffrey M. | |
dc.contributor.author | Jones, David R. | |
dc.contributor.author | Desta, Zeruesenay | |
dc.contributor.author | Flockhart, David A. | |
dc.contributor.author | Evans, James P. | |
dc.contributor.author | McLeod, Howard L. | |
dc.contributor.author | Carey, Lisa A. | |
dc.contributor.author | Irvin, William J. | |
dc.date.accessioned | 2017-12-15T16:47:17Z | |
dc.date.available | 2017-12-15T16:47:17Z | |
dc.date.issued | 2016-07 | |
dc.identifier.citation | Hertz, Daniel L.; Deal, Allison; Ibrahim, Joseph G.; Walko, Christine M.; Weck, Karen E.; Anderson, Steven; Magrinat, Gustav; Olajide, Oludamilola; Moore, Susan; Raab, Rachel; Carrizosa, Daniel R.; Corso, Steven; Schwartz, Garry; Graham, Mark; Peppercorn, Jeffrey M.; Jones, David R.; Desta, Zeruesenay; Flockhart, David A.; Evans, James P.; McLeod, Howard L.; Carey, Lisa A.; Irvin, William J. (2016). "Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity." The Oncologist 21(7): 795-803. | |
dc.identifier.issn | 1083-7159 | |
dc.identifier.issn | 1549-490X | |
dc.identifier.uri | https://hdl.handle.net/2027.42/139937 | |
dc.publisher | AlphaMed Press | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | Tamoxifen | |
dc.subject.other | CYP2D6 | |
dc.subject.other | Genotype | |
dc.subject.other | Race | |
dc.subject.other | Quality of life | |
dc.subject.other | Pharmacogenetics | |
dc.subject.other | Toxicity | |
dc.subject.other | Endoxifen | |
dc.title | Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity | |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Hematology and Oncology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, Michigan, USA | |
dc.contributor.affiliationother | Palmetto Hematology Oncology, Spartanburg, South Carolina, USA | |
dc.contributor.affiliationother | University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA | |
dc.contributor.affiliationother | Moffitt Cancer Center, Tampa, Florida, USA | |
dc.contributor.affiliationother | Laboratory Corporation of America, Burlington, North Carolina, USA | |
dc.contributor.affiliationother | Moses Cone Health Cancer Center, Greensboro, North Carolina, USA | |
dc.contributor.affiliationother | REX Hematology Oncology Associates, Raleigh, North Carolina, USA | |
dc.contributor.affiliationother | Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA | |
dc.contributor.affiliationother | Levine Cancer Institute, Charlotte, North Carolina, USA | |
dc.contributor.affiliationother | Levine Cancer Institute Concord, Concord, North Carolina, USA | |
dc.contributor.affiliationother | Waverly Hematology/Oncology, Cary, North Carolina, USA | |
dc.contributor.affiliationother | Duke University, Durham, North Carolina, USA | |
dc.contributor.affiliationother | Indiana University, Indianapolis, Indiana, USA | |
dc.contributor.affiliationother | Bon Secours Cancer Institute, Richmond, Virginia, USA | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/139937/1/onco0795-sup-0002.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/139937/2/onco0795-sup-0001.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/139937/3/onco0795.pdf | |
dc.identifier.doi | 10.1634/theoncologist.2015-0480 | |
dc.identifier.source | The Oncologist | |
dc.identifier.citedreference | RG Gray, D Rea, K Handley. aTTom: Long‐term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer. J Clin Oncol. 2013; 31 suppl: 5a. | |
dc.identifier.citedreference | C Davies, H Pan, J Godwin. Long‐term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor‐positive breast cancer: ATLAS, a randomised trial. Lancet. 2013; 381: 805 – 816. | |
dc.identifier.citedreference | WA Teft, IY Gong, B Dingle. CYP3A4 and seasonal variation in vitamin D status in addition to CYP2D6 contribute to therapeutic endoxifen level during tamoxifen therapy. Breast Cancer Res Treat. 2013; 139: 95 – 105. | |
dc.identifier.citedreference | LB Rangel, JL Taraba, CR Frei. Pharmacogenomic diversity of tamoxifen metabolites and estrogen receptor genes in Hispanics and non‐Hispanic whites with breast cancer. Breast Cancer Res Treat. 2014; 148: 571 – 580. | |
dc.identifier.citedreference | NA Limdi, TM Brown, Q Yan. Race influences warfarin dose changes associated with genetic factors. Blood. 2015; 126: 539 – 545. | |
dc.identifier.citedreference | SE Kimmel, B French, SE Kasner. A pharmacogenetic versus a clinical algorithm for warfarin dosing. N Engl J Med. 2013; 369: 2283 – 2293. | |
dc.identifier.citedreference | NL Henry, F Azzouz, Z Desta. Predictors of aromatase inhibitor discontinuation as a result of treatment‐emergent symptoms in early‐stage breast cancer. J Clin Oncol. 2012; 30: 936 – 942. | |
dc.identifier.citedreference | DL Hertz, AC Snavely, JP Evans. Does increasing the daily tamoxifen dose in patients with diminished CYP2D6 activity increase toxicity?. J Clin Oncol. 2014; 32 suppl: 561a. | |
dc.identifier.citedreference | I Sestak, R Kealy, M Nikoloff. Relationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: Results from the IBIS‐I trial. Br J Cancer. 2012; 107: 230 – 233. | |
dc.identifier.citedreference | V Dezentje, H Gelderblom, RN Schaik. CYP2D6 genotype in relation to hot flashes as tamoxifen side effect in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial. Breast Cancer Res Treat. 2014; 143: 171 – 179. | |
dc.identifier.citedreference | MP Goetz, JM Rae, VJ Suman. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol. 2005; 23: 9312 – 9318. | |
dc.identifier.citedreference | NL Henry, JM Rae, L Li. Association between CYP2D6 genotype and tamoxifen‐induced hot flashes in a prospective cohort. Breast Cancer Res Treat. 2009; 117: 571 – 575. | |
dc.identifier.citedreference | W Lorizio, AH Wu, MS Beattie. Clinical and biomarker predictors of side effects from tamoxifen. Breast Cancer Res Treat. 2012; 132: 1107 – 1118. | |
dc.identifier.citedreference | C Davies, J Godwin, R Gray. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient‐level meta‐analysis of randomised trials. Lancet. 2011; 378: 771 – 784. | |
dc.identifier.citedreference | MF Barginear, M Jaremko, I Peter. Increasing tamoxifen dose in breast cancer patients based on CYP2D6 genotypes and endoxifen levels: Effect on active metabolite isomers and the antiestrogenic activity score. Clin Pharmacol Ther. 2011; 90: 605 – 611. | |
dc.identifier.citedreference | Early Breast Cancer Trialists’ Collaborative Group. Tamoxifen for early breast cancer: An overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet. 1998; 351: 1451 – 1467. | |
dc.identifier.citedreference | JM Rae, MJ Sikora, NL Henry. Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients. Pharmacogenomics J. 2009; 9: 258 – 264. | |
dc.identifier.citedreference | K Kiyotani, T Mushiroda, CK Imamura. Dose‐adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients. Breast Cancer Res Treat. 2012; 131: 137 – 145. | |
dc.identifier.citedreference | LJ Fallowfield, SK Leaity, A Howell. Assessment of quality of life in women undergoing hormonal therapy for breast cancer: Validation of an endocrine symptom subscale for the FACT‐B. Breast Cancer Res Treat. 1999; 55: 189 – 199. | |
dc.identifier.citedreference | AL Stanton, CA Bernaards, PA Ganz. The BCPT symptom scales: A measure of physical symptoms for women diagnosed with or at risk for breast cancer. J Natl Cancer Inst. 2005; 97: 448 – 456. | |
dc.identifier.citedreference | WJ Irvin Jr, CM Walko, KE Weck. Genotype‐guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: A multicenter study. J Clin Oncol. 2011; 29: 3232 – 3239. | |
dc.identifier.citedreference | MM Regan, B Leyland‐Jones, M Bouzyk. CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine‐responsive breast cancer: The Breast International Group 1‐98 trial. J Natl Cancer Inst. 2012; 104: 441 – 451. | |
dc.identifier.citedreference | Rae JM, Drury S, Hayes DF et al. Lack of correlation between gene variants in tamoxifen metabolizing enzymes with primary endpoints in the ATAC trial. 33rd Annual San Antonio Breast Cancer Symposium; December 8–10, 2010; San Antonio, TX.; 2010 | |
dc.identifier.citedreference | W Schroth, MP Goetz, U Hamann. Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. JAMA. 2009; 302: 1429 – 1436. | |
dc.identifier.citedreference | MP Goetz, VJ Suman, TL Hoskin. CYP2D6 metabolism and patient outcome in the Austrian Breast and Colorectal Cancer Study Group trial (ABCSG) 8. Clin Cancer Res. 2013; 19: 500 – 507. | |
dc.identifier.citedreference | AH De Vries Schultink, W Zwart, SC Linn. Effects of pharmacogenetics on the pharmacokinetics and pharmacodynamics of tamoxifen. Clin Pharmacokinet. 2015; 54: 797 – 810. | |
dc.identifier.citedreference | DL Hertz, AC Snavely, HL McLeod. In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles. Br J Clin Pharmacol. 2015; 80: 1122 – 1130. | |
dc.identifier.citedreference | KR Crews, A Gaedigk, HM Dunnenberger. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther. 2012; 91: 321 – 326. | |
dc.identifier.citedreference | TE Mürdter, W Schroth, L Bacchus‐Gerybadze. Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma. Clin Pharmacol Ther. 2011; 89: 708 – 717. | |
dc.identifier.citedreference | RR Love, Z Desta, D Flockhart. CYP2D6 genotypes, endoxifen levels, and disease recurrence in 224 Filipino and Vietnamese women receiving adjuvant tamoxifen for operable breast cancer. SpringerPlus. 2013; 2: 52. | |
dc.identifier.citedreference | L Madlensky, L Natarajan, S Tchu. Tamoxifen metabolite concentrations, CYP2D6 genotype, and breast cancer outcomes. Clin Pharmacol Ther. 2011; 89: 718 – 725. | |
dc.identifier.citedreference | P Saladores, T Murdter, D Eccles. Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer. Pharmacogenomics J. 2014; 15: 84 – 94. | |
dc.identifier.citedreference | YC Lim, Z Desta, DA Flockhart. Endoxifen (4‐hydroxy‐N‐desmethyl‐tamoxifen) has anti‐estrogenic effects in breast cancer cells with potency similar to 4‐hydroxy‐tamoxifen. Cancer Chemother Pharmacol. 2005; 55: 471 – 478. | |
dc.identifier.citedreference | V Stearns, MD Johnson, JM Rae. Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst. 2003; 95: 1758 – 1764. | |
dc.identifier.citedreference | S Li, D Shen, J Shao. Endocrine‐therapy‐resistant ESR1 variants revealed by genomic characterization of breast‐cancer‐derived xenografts. Cell Reports. 2013; 4: 1116 – 1130. | |
dc.identifier.citedreference | DR Robinson, YM Wu, P Vats. Activating ESR1 mutations in hormone‐resistant metastatic breast cancer. Nat Genet. 2013; 45: 1446 – 1451. | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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