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Prognostic biomarkers in patients with human immunodeficiency virusâ positive disease with head and neck squamous cell carcinoma
dc.contributor.authorZhang, Hongzheng
dc.contributor.authorKim, Sungjin
dc.contributor.authorChen, Zhengjia
dc.contributor.authorNannapaneni, Sreenivas
dc.contributor.authorChen, Amy Y.
dc.contributor.authorMoore, Charles E.
dc.contributor.authorSica, Gabriel
dc.contributor.authorMosunjac, Marina
dc.contributor.authorNguyen, Minh Ly T.
dc.contributor.authorD’Souza, Gypsyamber
dc.contributor.authorCarey, Thomas E.
dc.contributor.authorPeterson, Lisa A.
dc.contributor.authorMcHugh, Jonathan B.
dc.contributor.authorGraham, Martin
dc.contributor.authorKomarck, Christine M.
dc.contributor.authorWolf, Gregory T.
dc.contributor.authorWalline, Heather M.
dc.contributor.authorBellile, Emily
dc.contributor.authorRiddell, James
dc.contributor.authorPai, Sara I.
dc.contributor.authorSidransky, David
dc.contributor.authorWestra, William H.
dc.contributor.authorWilliam, William N.
dc.contributor.authorLee, J. Jack
dc.contributor.authorEl‐naggar, Adel K.
dc.contributor.authorFerris, Robert L.
dc.contributor.authorSeethala, Raja
dc.contributor.authorGrandis, Jennifer R.
dc.contributor.authorChen, Zhuo Georgia
dc.contributor.authorSaba, Nabil F.
dc.contributor.authorShin, Dong M.
dc.date.accessioned2017-12-15T16:48:22Z
dc.date.available2019-02-01T19:56:25Zen
dc.date.issued2017-12
dc.identifier.citationZhang, Hongzheng; Kim, Sungjin; Chen, Zhengjia; Nannapaneni, Sreenivas; Chen, Amy Y.; Moore, Charles E.; Sica, Gabriel; Mosunjac, Marina; Nguyen, Minh Ly T.; D’Souza, Gypsyamber; Carey, Thomas E.; Peterson, Lisa A.; McHugh, Jonathan B.; Graham, Martin; Komarck, Christine M.; Wolf, Gregory T.; Walline, Heather M.; Bellile, Emily; Riddell, James; Pai, Sara I.; Sidransky, David; Westra, William H.; William, William N.; Lee, J. Jack; El‐naggar, Adel K. ; Ferris, Robert L.; Seethala, Raja; Grandis, Jennifer R.; Chen, Zhuo Georgia; Saba, Nabil F.; Shin, Dong M. (2017). "Prognostic biomarkers in patients with human immunodeficiency virusâ positive disease with head and neck squamous cell carcinoma." Head & Neck 39(12): 2433-2443.
dc.identifier.issn1043-3074
dc.identifier.issn1097-0347
dc.identifier.urihttps://hdl.handle.net/2027.42/139994
dc.description.abstractBackgroundWe examined the prognostic value of a panel of biomarkers in patients with squamous cell carcinoma of the head and neck (SCCHN) who were human immunodeficiency virus (HIV) positive (HIVâ positive head and neck cancer) and HIV negative (HIVâ negative head and neck cancer).MethodsTissue microarrays (TMAs) were constructed using tumors from 41 disease siteâ matched and ageâ matched HIVâ positive head and neck cancer cases and 44 HIVâ negative head and neck cancer controls. Expression of tumor biomarkers was assessed by immunohistochemistry (IHC) and correlations examined with clinical variables.ResultsExpression levels of the studied oncogenic and inflammatory tumor biomarkers were not differentially regulated by HIV status. Among patients with HIVâ positive head and neck cancer, laryngeal disease site (P = .003) and Clavienâ Dindo classification IV (CD4) counts <200 cells/μL (P = .01) were associated with poor prognosis. Multivariate analysis showed that p16 positivity was associated with improved overall survival (OS; P < .001) whereas increased expression of transforming growth factorâ beta (TGFâ β) was associated with poor clinical outcome (P = .001).ConclusionDisease site has significant effect on the expression of biomarkers. Expression of tumor TGFâ β could be a valuable addition to the conventional risk stratification equation for improving head and neck cancer disease management strategies.
dc.publisherJohn Wiley & Sons
dc.subject.otherprognosis
dc.subject.othersurvival
dc.subject.otherhuman immunodeficiency virus (HIV)
dc.subject.otherbiomarkers
dc.subject.otherhead and neck cancer
dc.titlePrognostic biomarkers in patients with human immunodeficiency virusâ positive disease with head and neck squamous cell carcinoma
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOtolaryngology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/139994/1/hed24911.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/139994/2/hed24911_am.pdf
dc.identifier.doi10.1002/hed.24911
dc.identifier.sourceHead & Neck
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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