Chromodomain Helicase DNA-Binding Proteins in Stem Cells and Human Developmental Diseases
dc.contributor.author | Micucci, Joseph A. | |
dc.contributor.author | Sperry, Ethan D. | |
dc.contributor.author | Martin, Donna M. | |
dc.date.accessioned | 2017-12-19T21:15:39Z | |
dc.date.available | 2017-12-19T21:15:39Z | |
dc.date.issued | 2015-01-08 | |
dc.identifier.citation | Micucci, Joseph A.; Sperry, Ethan D.; Martin, Donna M. (2015). "Chromodomain Helicase DNA-Binding Proteins in Stem Cells and Human Developmental Diseases." Stem Cells and Development 24 (8): 917-926. | |
dc.identifier.issn | 1547-3287 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/140206 | |
dc.description.abstract | Dynamic regulation of gene expression is vital for proper cellular development and maintenance of differentiated states. Over the past 20 years, chromatin remodeling and epigenetic modifications of histones have emerged as key controllers of rapid reversible changes in gene expression. Mutations in genes encoding enzymes that modify chromatin have also been identified in a variety of human neurodevelopmental disorders, ranging from isolated intellectual disability and autism spectrum disorder to multiple congenital anomaly conditions that affect major organ systems and cause severe morbidity and mortality. In this study, we review recent evidence that chromodomain helicase DNA-binding (CHD) proteins regulate stem cell proliferation, fate, and differentiation in a wide variety of tissues and organs. We also highlight known roles of CHD proteins in human developmental diseases and present current unanswered questions about the pleiotropic effects of CHD protein complexes, their genetic targets, nucleosome sliding functions, and enzymatic effects in cells and tissues. | |
dc.publisher | Mary Ann Liebert, Inc., publishers | |
dc.title | Chromodomain Helicase DNA-Binding Proteins in Stem Cells and Human Developmental Diseases | |
dc.type | Article | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/140206/1/scd.2014.0544.pdf | |
dc.identifier.doi | 10.1089/scd.2014.0544 | |
dc.identifier.source | Stem Cells and Development | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.