Image-Based, Fiber Guiding Scaffolds: A Platform for Regenerating Tissue Interfaces
dc.contributor.author | Park, Chan Ho | |
dc.contributor.author | Rios, Hector F. | |
dc.contributor.author | Taut, Andrei D. | |
dc.contributor.author | Padial-Molina, Miguel | |
dc.contributor.author | Flanagan, Colleen L. | |
dc.contributor.author | Pilipchuk, Sophia P. | |
dc.contributor.author | Hollister, Scott J. | |
dc.contributor.author | Giannobile, William V. | |
dc.date.accessioned | 2017-12-19T21:16:19Z | |
dc.date.available | 2017-12-19T21:16:19Z | |
dc.date.issued | 2013-11-04 | |
dc.identifier.citation | Park, Chan Ho; Rios, Hector F.; Taut, Andrei D.; Padial-Molina, Miguel; Flanagan, Colleen L.; Pilipchuk, Sophia P.; Hollister, Scott J.; Giannobile, William V. (2013). "Image-Based, Fiber Guiding Scaffolds: A Platform for Regenerating Tissue Interfaces." Tissue Engineering Part C: Methods 20 (7): 533-542. | |
dc.identifier.issn | 1937-3384 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/140247 | |
dc.description.abstract | In the oral and craniofacial complex, tooth loss is the most commonly acquired disfiguring injury. Among the most formidable challenges of reconstructing tooth-supporting osseous defects in the oral cavity is the regeneration of functional multi-tissue complexes involving bone, ligament, and tooth cementum. Furthermore, periodontal multi-tissue engineering with spatiotemporal orientation of the periodontal ligament (PDL) remains the most challenging obstacle for restoration of physiological loading and homeostasis. We report on the ability of a hybrid computer-designed scaffold?developed utilizing computed tomography?to predictably facilitate the regeneration and integration of dental supporting tissues. Here, we provide the protocol for rapid prototyping, manufacture, surgical implantation, and evaluation of dual-architecture scaffolds for controlling fiber orientation and facilitating morphogenesis of bone-ligament complexes. In contrast to conventional single-system methods of fibrous tissue formation, our protocol supports rigorous control of multi-compartmental scaffold architecture using computational scaffold design and manufacturing by 3D printing, as well as the evaluation of newly regenerated tissue physiology for clinical implementation. | |
dc.publisher | Mary Ann Liebert, Inc., publishers | |
dc.title | Image-Based, Fiber Guiding Scaffolds: A Platform for Regenerating Tissue Interfaces | |
dc.type | Article | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/140247/1/ten.tec.2013.0619.pdf | |
dc.identifier.doi | 10.1089/ten.tec.2013.0619 | |
dc.identifier.source | Tissue Engineering Part C: Methods | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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