VIDA: A Voxel-Based Dosimetry Method for Targeted Radionuclide Therapy Using Geant4
dc.contributor.author | Kost, Susan D. | |
dc.contributor.author | Dewaraja, Yuni K. | |
dc.contributor.author | Abramson, Richard G. | |
dc.contributor.author | Stabin, Michael G. | |
dc.date.accessioned | 2017-12-19T21:17:31Z | |
dc.date.available | 2017-12-19T21:17:31Z | |
dc.date.issued | 2015-01-16 | |
dc.identifier.citation | Kost, Susan D.; Dewaraja, Yuni K.; Abramson, Richard G.; Stabin, Michael G. (2015). "VIDA: A Voxel-Based Dosimetry Method for Targeted Radionuclide Therapy Using Geant4." Cancer Biotherapy and Radiopharmaceuticals 30 (1): 16-26. | |
dc.identifier.issn | 1084-9785 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/140327 | |
dc.description.abstract | We have developed the Voxel-Based Internal Dosimetry Application (VIDA) to provide patient-specific dosimetry in targeted radionuclide therapy performing Monte Carlo simulations of radiation transport with the Geant4 toolkit. The code generates voxel-level dose rate maps using anatomical and physiological data taken from individual patients. Voxel level dose rate curves are then fit and integrated to yield a spatial map of radiation absorbed dose. In this article, we present validation studies using established dosimetry results, including self-dose factors (DFs) from the OLINDA/EXM program for uniform activity in unit density spheres and organ self- and cross-organ DFs in the Radiation Dose Assessment Resource (RADAR) reference adult phantom. The comparison with reference data demonstrated agreement within 5% for self-DFs to spheres and reference phantom source organs for four common radionuclides used in targeted therapy (131I, 90Y, 111In, 177Lu). Agreement within 9% was achieved for cross-organ DFs. We also present dose estimates to normal tissues and tumors from studies of two non-Hodgkin Lymphoma patients treated by 131I radioimmunotherapy, with comparison to results generated independently with another dosimetry code. A relative difference of 12% or less was found between methods for mean absorbed tumor doses accounting for tumor regression. | |
dc.publisher | Mary Ann Liebert, Inc., publishers | |
dc.title | VIDA: A Voxel-Based Dosimetry Method for Targeted Radionuclide Therapy Using Geant4 | |
dc.type | Article | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/140327/1/cbr.2014.1713.pdf | |
dc.identifier.doi | 10.1089/cbr.2014.1713 | |
dc.identifier.source | Cancer Biotherapy and Radiopharmaceuticals | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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