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Stimulation of liver growth and DNA synthesis by glucosylceramide
dc.contributor.authorDatta, Subhash C.
dc.contributor.authorRadin, Norman S.
dc.date.accessioned2018-02-05T16:37:24Z
dc.date.available2018-02-05T16:37:24Z
dc.date.issued1988-05
dc.identifier.citationDatta, Subhash C.; Radin, Norman S. (1988). "Stimulation of liver growth and DNA synthesis by glucosylceramide." Lipids 23(5): 508-510.
dc.identifier.issn0024-4201
dc.identifier.issn1558-9307
dc.identifier.urihttps://hdl.handle.net/2027.42/141613
dc.description.abstractThe nature of the growth‐stimulating effect of glucosylceramide was studied. Mice were injected intraperitoneally with emulsified glucosylceramide and conduritol B epoxide, an inhibitor of cerebroside glucosidase. Within one or two days, the liver grew 18–24%, as reported. Two enzymes involved in DNA synthesis also increased more than the weight. The total liver activity of thymidine kinase increased 46–73%, and the total activity of ornithine decarboxylase increased as much as 101%. It is suggested that elevated liver levels of glucocerebroside stimulate cell proliferation through a relatively direct mechanism.
dc.publisherSpringer‐Verlag
dc.publisherWiley Periodicals, Inc.
dc.titleStimulation of liver growth and DNA synthesis by glucosylceramide
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelScience (General)
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/141613/1/lipd0508.pdf
dc.identifier.doi10.1007/BF02535529
dc.identifier.sourceLipids
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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